119716 20250127144950.0 doi 10.1038/s41598-022-21144-0 sideral 130570 ART-2022-130570 eng Comín, Jessica Estimation of the mutation rate of Mycobacterium tuberculosis in cases with recurrent tuberculosis using whole genome sequencing 2022 Access copy available to the general public Unrestricted The study of tuberculosis latency is problematic due to the difficulty of isolating the bacteria in the dormancy state. Despite this, several in vivo approaches have been taken to mimic the latency process. Our group has studied the evolution of the bacteria in 18 cases of recurrent tuberculosis. We found that HIV positive patients develop recurrent tuberculosis earlier, generally in the first two years (p value = 0.041). The genome of the 36 Mycobacterium tuberculosis paired isolates (first and relapsed isolates) showed that none of the SNPs found within each pair was observed more than once, indicating that they were not directly related to the recurrence process. Moreover, some IS6110 movements were found in the paired isolates, indicating the presence of different clones within the patient. Finally, our results suggest that the mutation rate remains constant during all the period as no correlation was found between the number of SNPs and the time to relapse. info:eu-repo/grantAgreement/ES/DGA-FEDER/Construyendo Europa desde Aragón info:eu-repo/grantAgreement/ES/ISCIII/FIS18-0336 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.6 2022 MULTIDISCIPLINARY SCIENCES 22 / 73 = 0.301 2022 Q2 T1 0.973 2022 Multidisciplinary 2022 Q1 7.5 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Cebollada, Alberto Iglesias, María José Universidad de Zaragoza (orcid)0000-0003-2266-8602 Ibarz, Daniel Universidad de Zaragoza Viñuelas, Jesús Universidad de Zaragoza (orcid)0000-0003-2044-6782 Torres, Luis Sahagún, Juan Universidad de Zaragoza Lafoz, María Carmen Esteban de Juanas, Felipe Malo, María Carmen Samper, Sofía Universidad de Zaragoza (orcid)0000-0002-3011-2519 1011 630 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Microbiología 1011 615 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Medic.Prevent.Salud Públ. 12, 1 (2022), 16728 [10 pp.] Sci. rep. (Nat. Publ. Group) Scientific reports (Nature Publishing Group) 2045-2322 1917583 http://zaguan.unizar.es/record/119716/files/texto_completo.pdf Versión publicada 2599934 http://zaguan.unizar.es/record/119716/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:119716 articulos driver 2025-01-27-14:45:31 ARTICLE