000119730 001__ 119730 000119730 005__ 20240319081023.0 000119730 0247_ $$2doi$$a10.3390/ani12182388 000119730 0248_ $$2sideral$$a130564 000119730 037__ $$aART-2022-130564 000119730 041__ $$aeng 000119730 100__ $$0(orcid)0000-0002-0680-9957$$aBorobia, Marta$$uUniversidad de Zaragoza 000119730 245__ $$aCopper poisoning, a deadly hazard for sheep 000119730 260__ $$c2022 000119730 5060_ $$aAccess copy available to the general public$$fUnrestricted 000119730 5203_ $$aCopper (Cu) is an essential microelement for animals. However, sheep are particularly susceptible to Cu intoxication, a deadly disease reported worldwide. The risk of developing this poisoning is higher in vulnerable breeds and in intensively managed lambs or milk sheep. Two types of Cu intoxication can occur depending on the chronic or acute exposure to Cu. In chronic Cu poisoning (CCP), the most common form, Cu is accumulated in the liver during a subclinical period. A low intake of Cu antagonists (molybdenum, sulphur, iron, or zinc) favours Cu accumulation. The sudden release of Cu into the blood causes acute haemolysis with anaemia, haemoglobinuria, jaundice and death within 1–2 days. Acute Cu poisoning is related to the accidental administration or ingestion of toxic amounts of Cu. Acute oral exposure to Cu causes severe gastroenteritis, shock and death. Collapse and death occur shortly after parenteral administration. The diagnosis is based on history, clinical, gross pathological, histological and toxicological findings. Treatment of sheep with severe clinical signs often has poor success but is very effective during the Cu accumulation phase. Different therapies, based on either chelating agents or Cu antagonists, have been used to treat and prevent CCP. 000119730 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000119730 590__ $$a3.0$$b2022 000119730 592__ $$a0.684$$b2022 000119730 591__ $$aVETERINARY SCIENCES$$b13 / 144 = 0.09$$c2022$$dQ1$$eT1 000119730 593__ $$aVeterinary (miscellaneous)$$c2022$$dQ1 000119730 591__ $$aAGRICULTURE, DAIRY & ANIMAL SCIENCE$$b12 / 62 = 0.194$$c2022$$dQ1$$eT1 000119730 593__ $$aAnimal Science and Zoology$$c2022$$dQ1 000119730 594__ $$a4.2$$b2022 000119730 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000119730 700__ $$0(orcid)0000-0001-6209-4282$$aVillanueva-Saz, Sergio$$uUniversidad de Zaragoza 000119730 700__ $$0(orcid)0000-0002-7655-2472$$aRuiz de Arcaute, Marta$$uUniversidad de Zaragoza 000119730 700__ $$0(orcid)0000-0002-2557-4890$$aFernández, Antonio$$uUniversidad de Zaragoza 000119730 700__ $$0(orcid)0000-0003-2957-1379$$aVerde, María Teresa$$uUniversidad de Zaragoza 000119730 700__ $$0(orcid)0000-0002-4655-9171$$aGonzález, José María$$uUniversidad de Zaragoza 000119730 700__ $$0(orcid)0000-0002-4557-6033$$aNavarro, Teresa$$uUniversidad de Zaragoza 000119730 700__ $$aBenito, Alfredo A. 000119730 700__ $$aArnal, José Luis 000119730 700__ $$0(orcid)0000-0003-3792-287X$$aDe las Heras, Marcelo$$uUniversidad de Zaragoza 000119730 700__ $$0(orcid)0000-0002-0313-5926$$aOrtín, Aurora$$uUniversidad de Zaragoza 000119730 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal 000119730 7102_ $$11009$$2617$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Medicina y Cirugía Animal 000119730 773__ $$g12, 18 (2022), 2388 [16pp.]$$pAnimals (Basel)$$tAnimals$$x2076-2615 000119730 8564_ $$s1115241$$uhttps://zaguan.unizar.es/record/119730/files/texto_completo.pdf$$yVersión publicada 000119730 8564_ $$s2697107$$uhttps://zaguan.unizar.es/record/119730/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000119730 909CO $$ooai:zaguan.unizar.es:119730$$particulos$$pdriver 000119730 951__ $$a2024-03-18-16:28:06 000119730 980__ $$aARTICLE