119730 20240319081023.0 doi 10.3390/ani12182388 sideral 130564 ART-2022-130564 eng Borobia, Marta Universidad de Zaragoza (orcid)0000-0002-0680-9957 Copper poisoning, a deadly hazard for sheep 2022 Access copy available to the general public Unrestricted Copper (Cu) is an essential microelement for animals. However, sheep are particularly susceptible to Cu intoxication, a deadly disease reported worldwide. The risk of developing this poisoning is higher in vulnerable breeds and in intensively managed lambs or milk sheep. Two types of Cu intoxication can occur depending on the chronic or acute exposure to Cu. In chronic Cu poisoning (CCP), the most common form, Cu is accumulated in the liver during a subclinical period. A low intake of Cu antagonists (molybdenum, sulphur, iron, or zinc) favours Cu accumulation. The sudden release of Cu into the blood causes acute haemolysis with anaemia, haemoglobinuria, jaundice and death within 1–2 days. Acute Cu poisoning is related to the accidental administration or ingestion of toxic amounts of Cu. Acute oral exposure to Cu causes severe gastroenteritis, shock and death. Collapse and death occur shortly after parenteral administration. The diagnosis is based on history, clinical, gross pathological, histological and toxicological findings. Treatment of sheep with severe clinical signs often has poor success but is very effective during the Cu accumulation phase. Different therapies, based on either chelating agents or Cu antagonists, have been used to treat and prevent CCP. info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 3.0 2022 VETERINARY SCIENCES 13 / 144 = 0.09 2022 Q1 T1 AGRICULTURE, DAIRY & ANIMAL SCIENCE 12 / 62 = 0.194 2022 Q1 T1 0.684 2022 Veterinary (miscellaneous) 2022 Q1 Animal Science and Zoology 2022 Q1 4.2 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Villanueva-Saz, Sergio Universidad de Zaragoza (orcid)0000-0001-6209-4282 Ruiz de Arcaute, Marta Universidad de Zaragoza (orcid)0000-0002-7655-2472 Fernández, Antonio Universidad de Zaragoza (orcid)0000-0002-2557-4890 Verde, María Teresa Universidad de Zaragoza (orcid)0000-0003-2957-1379 González, José María Universidad de Zaragoza (orcid)0000-0002-4655-9171 Navarro, Teresa Universidad de Zaragoza (orcid)0000-0002-4557-6033 Benito, Alfredo A. Arnal, José Luis De las Heras, Marcelo Universidad de Zaragoza (orcid)0000-0003-3792-287X Ortín, Aurora Universidad de Zaragoza (orcid)0000-0002-0313-5926 1009 773 Universidad de Zaragoza Dpto. Patología Animal Área Sanidad Animal 1009 617 Universidad de Zaragoza Dpto. Patología Animal Área Medicina y Cirugía Animal 12, 18 (2022), 2388 [16pp.] Animals (Basel) Animals 2076-2615 1115241 http://zaguan.unizar.es/record/119730/files/texto_completo.pdf Versión publicada 2697107 http://zaguan.unizar.es/record/119730/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:119730 articulos driver 2024-03-18-16:28:06 ARTICLE