000119751 001__ 119751
000119751 005__ 20221115154456.0
000119751 0248_ $$2sideral$$a129525
000119751 037__ $$aART-2018-129525
000119751 041__ $$aeng
000119751 100__ $$aD. Jary
000119751 245__ $$aBedaquiline loaded lipid nanoparticles: a promising candidate for TB treatment
000119751 260__ $$c2018
000119751 5060_ $$aAccess copy available to the general public$$fUnrestricted
000119751 5203_ $$aFour different kinds of Lipid Nanoparticles (LNP) encapsulating bedaquiline have been tested in order to evaluate the possibility to decrease adverse effects of this very efficient and recent antibiotic. The parameters that are studied among these different types of LNP are the surface charge as well as targeting of macrophages through trimannose groups grafted to the surface. It was found that these nanocarriers could encapsulate bedaquiline with a very high loading efficiency, exhibited a very good colloidal stability in storage conditions as well as in biological media, and an excellent compatibility with animal cells. Finally, first in vivo evaluation showed that these carriers are able to accumulate strongly in the lungs and that the almost neutral ones without targeting ligands could be the best candidate for tuberculosis treatment.
000119751 536__ $$9info:eu-repo/grantAgreement/EC/FP7/604237/EU/Nanotherapeutics for antibiotic resistant emerging bacterial pathogens/NAREB
000119751 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000119751 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000119751 700__ $$aA. Hibbits
000119751 700__ $$aT. Lozano-Fernández
000119751 700__ $$aD. Pérez
000119751 700__ $$0(orcid)0000-0002-0111-4697$$aA. Lucía$$uUniversidad de Zaragoza
000119751 700__ $$0(orcid)0000-0003-2076-844X$$aJ.A. Aínsa$$uUniversidad de Zaragoza
000119751 700__ $$aN. Redinger
000119751 700__ $$aU. E. Schaible
000119751 700__ $$aJ.M. Coya Raboso
000119751 700__ $$aL. Tailleux
000119751 700__ $$aB. Gicquel
000119751 700__ $$aF. Navarro
000119751 7102_ $$11008$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Med.Pr.,Sal.Públ.$$cÁrea Microbiología
000119751 773__ $$g3 (2018), 59-62$$tTechConnect Briefs
000119751 85641 $$uhttps://briefs.techconnect.org/papers/bedaquiline-loaded-lipid-nanoparticles-a-promising-candidate-for-tb-treatment/$$zTexto completo de la revista
000119751 8564_ $$s998037$$uhttps://zaguan.unizar.es/record/119751/files/texto_completo.pdf$$yVersión publicada
000119751 8564_ $$s3274096$$uhttps://zaguan.unizar.es/record/119751/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000119751 909CO $$ooai:zaguan.unizar.es:119751$$particulos$$pdriver
000119751 951__ $$a2022-11-15-12:20:32
000119751 980__ $$aARTICLE