000119763 001__ 119763
000119763 005__ 20240319081027.0
000119763 0247_ $$2doi$$a10.3390/jcm11195808
000119763 0248_ $$2sideral$$a130534
000119763 037__ $$aART-2022-130534
000119763 041__ $$aeng
000119763 100__ $$0(orcid)0000-0001-5603-3045$$aBarrio, Eva$$uUniversidad de Zaragoza
000119763 245__ $$aIdentification of miRNAs involved in foetal growth restriction due to maternal smoking during pregnancy
000119763 260__ $$c2022
000119763 5060_ $$aAccess copy available to the general public$$fUnrestricted
000119763 5203_ $$aIntroduction: Smoking during pregnancy is associated with reduced foetal growth, amongst other effects. Epigenetic modification in the foetus and placenta during embryonic development as a result of changes in the function of miRNAs is one of the pathophysiological mechanisms responsible for this. This dysregulation may be due to environmental changes or toxins such as tobacco. Objective: To study the impact of smoking during pregnancy and its role in intrauterine growth restriction via hypermethylated miRNAs. Materials and methods: The differences in methylation patterns for miRNAs in umbilical cord blood from low-birth-weight newborns of smoking mothers were compared with those from normal-weight newborns using MedIP-seq (StarArray). Results: Seven hypermethylated miRNAs were identified in the epigenetic study of cord blood from low-birth-weight newborns of smoking mothers in our sample. The miRNAs found to be hypermethylated were: MIR7-1, MIR3918, MIR1244-1, MIR4721, MIR25, MIR93, MIR3656. Conclusion: Intrauterine exposure to tobacco induces hypermethylation-mediated miRNA silencing in low-birth-weight newborns by modifying the expression of factors involved in vascular development, growth, and adaptation to hypoxia.
000119763 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B19-20R
000119763 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000119763 590__ $$a3.9$$b2022
000119763 592__ $$a0.935$$b2022
000119763 591__ $$aMEDICINE, GENERAL & INTERNAL$$b58 / 169 = 0.343$$c2022$$dQ2$$eT2
000119763 593__ $$aMedicine (miscellaneous)$$c2022$$dQ1
000119763 594__ $$a5.4$$b2022
000119763 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000119763 700__ $$aQuirós, Alba
000119763 700__ $$0(orcid)0000-0003-0691-0251$$aLerma-Puertas, Diego$$uUniversidad de Zaragoza
000119763 700__ $$0(orcid)0000-0003-2832-2266$$aLabarta, José I.$$uUniversidad de Zaragoza
000119763 700__ $$0(orcid)0000-0003-0335-0404$$aGascón-Catalán, Ana$$uUniversidad de Zaragoza
000119763 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000119763 7102_ $$11003$$2443$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Histología
000119763 7102_ $$11013$$2645$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Obstetricia y Ginecología
000119763 7102_ $$11011$$2670$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Pediatría
000119763 773__ $$g11, 19 (2022), 5808 [11 pp.]$$pJ. clin.med.$$tJournal of Clinical Medicine$$x2077-0383
000119763 8564_ $$s287094$$uhttps://zaguan.unizar.es/record/119763/files/texto_completo.pdf$$yVersión publicada
000119763 8564_ $$s2874431$$uhttps://zaguan.unizar.es/record/119763/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000119763 909CO $$ooai:zaguan.unizar.es:119763$$particulos$$pdriver
000119763 951__ $$a2024-03-18-16:52:02
000119763 980__ $$aARTICLE