119763 20240319081027.0 doi 10.3390/jcm11195808 sideral 130534 ART-2022-130534 eng Barrio, Eva Universidad de Zaragoza (orcid)0000-0001-5603-3045 Identification of miRNAs involved in foetal growth restriction due to maternal smoking during pregnancy 2022 Access copy available to the general public Unrestricted Introduction: Smoking during pregnancy is associated with reduced foetal growth, amongst other effects. Epigenetic modification in the foetus and placenta during embryonic development as a result of changes in the function of miRNAs is one of the pathophysiological mechanisms responsible for this. This dysregulation may be due to environmental changes or toxins such as tobacco. Objective: To study the impact of smoking during pregnancy and its role in intrauterine growth restriction via hypermethylated miRNAs. Materials and methods: The differences in methylation patterns for miRNAs in umbilical cord blood from low-birth-weight newborns of smoking mothers were compared with those from normal-weight newborns using MedIP-seq (StarArray). Results: Seven hypermethylated miRNAs were identified in the epigenetic study of cord blood from low-birth-weight newborns of smoking mothers in our sample. The miRNAs found to be hypermethylated were: MIR7-1, MIR3918, MIR1244-1, MIR4721, MIR25, MIR93, MIR3656. Conclusion: Intrauterine exposure to tobacco induces hypermethylation-mediated miRNA silencing in low-birth-weight newborns by modifying the expression of factors involved in vascular development, growth, and adaptation to hypoxia. info:eu-repo/grantAgreement/ES/DGA/B19-20R info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 3.9 2022 MEDICINE, GENERAL & INTERNAL 58 / 169 = 0.343 2022 Q2 T2 0.935 2022 Medicine (miscellaneous) 2022 Q1 5.4 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Quirós, Alba Lerma-Puertas, Diego Universidad de Zaragoza (orcid)0000-0003-0691-0251 Labarta, José I. Universidad de Zaragoza (orcid)0000-0003-2832-2266 Gascón-Catalán, Ana Universidad de Zaragoza (orcid)0000-0003-0335-0404 1006 255 Universidad de Zaragoza Dpto. Fisiatría y Enfermería Área Enfermería 1003 443 Universidad de Zaragoza Dpto. Anatom.Histolog.Humanas Area Histología 1013 645 Universidad de Zaragoza Dpto. Cirugía Área Obstetricia y Ginecología 1011 670 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Pediatría 11, 19 (2022), 5808 [11 pp.] J. clin.med. Journal of Clinical Medicine 2077-0383 287094 http://zaguan.unizar.es/record/119763/files/texto_completo.pdf Versión publicada 2874431 http://zaguan.unizar.es/record/119763/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:119763 articulos driver 2024-03-18-16:52:02 ARTICLE