000119808 001__ 119808
000119808 005__ 20240319081004.0
000119808 0247_ $$2doi$$a10.3389/fnana.2022.984052
000119808 0248_ $$2sideral$$a130743
000119808 037__ $$aART-2022-130743
000119808 041__ $$aeng
000119808 100__ $$aMartínez-Gil, Natalia
000119808 245__ $$aCellular and molecular alterations in neurons and glial cells in inherited retinal degeneration
000119808 260__ $$c2022
000119808 5060_ $$aAccess copy available to the general public$$fUnrestricted
000119808 5203_ $$aMultiple gene mutations have been associated with inherited retinal dystrophies (IRDs). Despite the spectrum of phenotypes caused by the distinct mutations, IRDs display common physiopathology features. Cell death is accompanied by inflammation and oxidative stress. The vertebrate retina has several attributes that make this tissue vulnerable to oxidative and nitrosative imbalance. The high energy demands and active metabolism in retinal cells, as well as their continuous exposure to high oxygen levels and light-induced stress, reveal the importance of tightly regulated homeostatic processes to maintain retinal function, which are compromised in pathological conditions. In addition, the subsequent microglial activation and gliosis, which triggers the secretion of pro-inflammatory cytokines, chemokines, trophic factors, and other molecules, further worsen the degenerative process. As the disease evolves, retinal cells change their morphology and function. In disease stages where photoreceptors are lost, the remaining neurons of the retina to preserve their function seek out for new synaptic partners, which leads to a cascade of morphological alterations in retinal cells that results in a complete remodeling of the tissue. In this review, we describe important molecular and morphological changes in retinal cells that occur in response to oxidative stress and the inflammatory processes underlying IRDs.
000119808 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B08-17R$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI20-00740$$9info:eu-repo/grantAgreement/ES/ISCIII/RETICS-FEDER-RD16-0008-0016$$9info:eu-repo/grantAgreement/ES/MEC/FPU16-04114$$9info:eu-repo/grantAgreement/ES/MICINN-FEDER/PID2019-106230RB-I00
000119808 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000119808 590__ $$a2.9$$b2022
000119808 592__ $$a1.143$$b2022
000119808 591__ $$aANATOMY & MORPHOLOGY$$b2 / 20 = 0.1$$c2022$$dQ1$$eT1
000119808 593__ $$aAnatomy$$c2022$$dQ1
000119808 591__ $$aNEUROSCIENCES$$b174 / 272 = 0.64$$c2022$$dQ3$$eT2
000119808 593__ $$aNeuroscience (miscellaneous)$$c2022$$dQ2
000119808 593__ $$aCellular and Molecular Neuroscience$$c2022$$dQ2
000119808 594__ $$a5.0$$b2022
000119808 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000119808 700__ $$aManeu, Victoria
000119808 700__ $$aKutsyr, Oksana
000119808 700__ $$aFernández-Sánchez, Laura
000119808 700__ $$aSánchez-Sáez, Xavier
000119808 700__ $$aSánchez-Castillo, Carla
000119808 700__ $$aCampello, Laura
000119808 700__ $$aLax, Pedro
000119808 700__ $$0(orcid)0000-0003-0349-9997$$aPinilla, Isabel$$uUniversidad de Zaragoza
000119808 700__ $$aCuenca, Nicolás
000119808 7102_ $$11013$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Oftalmología
000119808 773__ $$g16 (2022), 984052 [18 pp.]$$pFront. neuroanat.$$tFRONTIERS IN NEUROANATOMY$$x1662-5129
000119808 8564_ $$s12959618$$uhttps://zaguan.unizar.es/record/119808/files/texto_completo.pdf$$yVersión publicada
000119808 8564_ $$s2143458$$uhttps://zaguan.unizar.es/record/119808/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000119808 909CO $$ooai:zaguan.unizar.es:119808$$particulos$$pdriver
000119808 951__ $$a2024-03-18-14:24:45
000119808 980__ $$aARTICLE