000119830 001__ 119830
000119830 005__ 20240319081006.0
000119830 0247_ $$2doi$$a10.3390/nu14091986
000119830 0248_ $$2sideral$$a129159
000119830 037__ $$aART-2022-129159
000119830 041__ $$aeng
000119830 100__ $$aReigada, Inés
000119830 245__ $$aAlterations in bacterial metabolism contribute to the Lifespan Extension Exerted by Guarana in Caenorhabditis elegans
000119830 260__ $$c2022
000119830 5060_ $$aAccess copy available to the general public$$fUnrestricted
000119830 5203_ $$aGuarana (Paullinia cupana) is a widely consumed nutraceutical with various health benefits supported by scientific evidence. However, its indirect health impacts through the gut microbi-ota have not been studied. Caenorhabditis elegans is a useful model to study both the direct and indirect effects of nutraceuticals, as the intimate association of the worm with the metabolites produced by Escherichia coli is a prototypic simplified model of our gut microbiota. We prepared an ethanoic extract of guarana seeds and assessed its antioxidant capacity in vitro, with a 2, 2-diphenyl-1-pic-rylhydrazyl (DPPH) assay, and in vivo, utilizing C. elegans. Additionally, we studied the impact of this extract on C. elegans lifespan, utilizing both viable and non-viable E. coli, and assessed the impact of guarana on E. coli folate production. The extract showed high antioxidant capacity, and it extended worm lifespan. However, the antioxidant and life-extending effects did not correlate in terms of the extract concentration. The extract-induced life extension was also less significant when utilizing dead E. coli, which may indicate that the effects of guarana on the worms work partly through modifications on E. coli metabolism. Following this observation, guarana was found to decrease E. coli folate production, revealing one possible route for its beneficial effects. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
000119830 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000119830 590__ $$a5.9$$b2022
000119830 592__ $$a1.291$$b2022
000119830 591__ $$aNUTRITION & DIETETICS$$b17 / 87 = 0.195$$c2022$$dQ1$$eT1
000119830 593__ $$aNutrition and Dietetics$$c2022$$dQ1
000119830 593__ $$aFood Science$$c2022$$dQ1
000119830 594__ $$a9.0$$b2022
000119830 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000119830 700__ $$aKapp, Karmen
000119830 700__ $$aMaynard, Claire
000119830 700__ $$aWeinkove, David
000119830 700__ $$0(orcid)0000-0002-2231-7565$$aValero, Marta Sofía$$uUniversidad de Zaragoza
000119830 700__ $$aLanga, Elisa
000119830 700__ $$aHanski, Leena
000119830 700__ $$aGómez-Rincón, Carlota
000119830 7102_ $$11012$$2410$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Fisiología
000119830 773__ $$g14, 9 (2022), 1986 [15 pp.]$$pNutrients$$tNutrients$$x2072-6643
000119830 8564_ $$s1360491$$uhttps://zaguan.unizar.es/record/119830/files/texto_completo.pdf$$yVersión publicada
000119830 8564_ $$s2761207$$uhttps://zaguan.unizar.es/record/119830/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000119830 909CO $$ooai:zaguan.unizar.es:119830$$particulos$$pdriver
000119830 951__ $$a2024-03-18-14:36:15
000119830 980__ $$aARTICLE