119840 20240319081011.0 doi 10.3390/pharmaceutics14071417 sideral 130351 ART-2022-130351 eng Fernández-Carro, Estibaliz Modeling an optimal 3D Skin-on-Chip within microfluidic devices for pharmacological studies 2022 Access copy available to the general public Unrestricted Preclinical research remains hampered by an inadequate representation of human tissue environments which results in inaccurate predictions of a drug candidate''s effects and target''s suitability. While human 2D and 3D cell cultures and organoids have been extensively improved to mimic the precise structure and function of human tissues, major challenges persist since only few of these models adequately represent the complexity of human tissues. The development of skin-on-chip technology has allowed the transition from static 3D cultures to dynamic 3D cultures resembling human physiology. The integration of vasculature, immune system, or the resident microbiome in the next generation of SoC, with continuous detection of changes in metabolism, would potentially overcome the current limitations, providing reliable and robust results and mimicking the complex human skin. This review aims to provide an overview of the biological skin constituents and mechanical requirements that should be incorporated in a human skin-on-chip, permitting pharmacological, toxicological, and cosmetic tests closer to reality. info:eu-repo/grantAgreement/ES/DGA/GIS096 info:eu-repo/grantAgreement/ES/DGA/LMP233_21 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 5.4 2022 PHARMACOLOGY & PHARMACY 50 / 278 = 0.18 2022 Q1 T1 0.795 2022 Pharmaceutical Science 2022 Q1 6.9 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Angenent, Maricke Gracia-Cazaña, Tamara Universidad de Zaragoza Gilaberte, Yolanda Universidad de Zaragoza (orcid)0000-0001-8034-3617 Alcaine, Clara Universidad de Zaragoza (orcid)0000-0002-7854-8856 Ciriza, Jesús Universidad de Zaragoza (orcid)0000-0002-8666-622X 1006 255 Universidad de Zaragoza Dpto. Fisiatría y Enfermería Área Enfermería 1003 443 Universidad de Zaragoza Dpto. Anatom.Histolog.Humanas Area Histología 1007 183 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Área Dermatología 14, 7 (2022), 1417 [22 pp.] Pharmaceutics Pharmaceutics 1999-4923 2419088 http://zaguan.unizar.es/record/119840/files/texto_completo.pdf Versión publicada 2776957 http://zaguan.unizar.es/record/119840/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:119840 articulos driver 2024-03-18-15:09:32 ARTICLE