119866 20250210083428.0 doi 10.3390/ijms232012424 sideral 130790 ART-2022-130790 eng Feiner Solís, Ángela The Effects of Vitamin D Supplementation in COVID-19 Patients: A Systematic Review 2022 Access copy available to the general public Unrestricted Vitamin D has an immune-modulating effect on respiratory tract infections. For this reason, it has been proposed as part of the treatment in COVID-19. Furthermore, vitamin D deficiency has been associated with worse clinical outcomes of this disease. The aim of this systematic review was to determine whether vitamin D supplementation modifies the disease course. Therefore, eleven studies involving randomised clinical trials are analysed, in which groups of COVID-19 patients with or without vitamin D supplementation as part of the treatment are compared. A control group was treated with best available therapy, and in some of the clinical trials, also with a placebo. According to the outcomes, it seems that patients benefit from receiving a daily or maintained in time vitamin D dose regardless of vitamin D serum levels at the beginning of the trial. The administration of a single vitamin D dose does not seem to have any effect on the health status of these patients. However, the outcomes are heterogeneous and larger clinical trials are necessary. info:eu-repo/grantAgreement/ES/DGA/A05-20R info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 5.6 2022 BIOCHEMISTRY & MOLECULAR BIOLOGY 66 / 285 = 0.232 2022 Q1 T1 CHEMISTRY, MULTIDISCIPLINARY 52 / 178 = 0.292 2022 Q2 T1 1.154 2022 Medicine (miscellaneous) 2022 Q1 Physical and Theoretical Chemistry 2022 Q1 Computer Science Applications 2022 Q1 Inorganic Chemistry 2022 Q1 Spectroscopy 2022 Q1 Organic Chemistry 2022 Q1 Molecular Biology 2022 Q2 Catalysis 2022 Q2 7.8 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Avedillo Salas, Ana Universidad de Zaragoza (orcid)0000-0003-2153-0417 Luesma Bartolomé, María José Universidad de Zaragoza (orcid)0000-0003-4071-1467 Santander Ballestín, Sonia Universidad de Zaragoza (orcid)0000-0002-1275-2600 1003 027 Universidad de Zaragoza Dpto. Anatom.Histolog.Humanas Area Anatom.Embriol.Humana 1012 315 Universidad de Zaragoza Dpto. Farmac.Fisiol.y Med.L.F. Área Farmacología 23, 20 (2022), 12424 [15 pp.] Int. j. mol. sci. International Journal of Molecular Sciences 1661-6596 1196260 http://zaguan.unizar.es/record/119866/files/texto_completo.pdf Versión publicada 2670113 http://zaguan.unizar.es/record/119866/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:119866 articulos driver 2025-02-10-08:31:16 ARTICLE