119897 20240319081016.0 doi 10.3390/biomedicines10092314 sideral 130793 ART-2022-130793 eng Fernández-Espinosa, Guisela (orcid)0000-0003-1234-9712 Choroidal and Retinal Thicknesses in Type 2 Diabetes Mellitus with Moderate Diabetic Retinopathy Measured by Swept Source OCT 2022 Access copy available to the general public Unrestricted Background: To study choroidal thickness (CT) in type 2 diabetes mellitus (DM2) patients with moderate diabetic retinopathy (DR) and to correlate with changes in retinal thickness (RT) with swept-source OCT (SS-OCT) compared to healthy subjects. Methods: Fifty-four DM2 patients with moderate DR without diabetic macular edema (DME) and 73 age-matched healthy subjects were evaluated using SS-OCT to measure changes in total RT and CT in the nine areas of the Early Treatment Diabetic Retinopathy Study (ETDRS) macular grid. Results: The mean age was 64.06 ± 11.98 years and 60.79 ± 8.62 years in the diabetic and control groups, respectively. Total RT showed statistically significant differences in the temporal inner area, with higher values in the DM2 group (p = 0.010). CT did not show differences between the groups. There was a significant negative correlation between RT and age in all of the outer ETDRS areas and a positive significant correlation in the central area for the DM2 group. There was also a negative significant correlation between CT and age in all of the ETDRS areas except for the inferior inner area. In the DM2 group, a negative correlation was observed between RT and CT in the central area (p = 0.039) and in both horizontal parafoveal areas (temporal inner, p = 0.028; nasal inner, p= 0.003). Conclusion: DM2 patients with moderate DR have no changes with regard to CT. Both CT and RT decreased with age in DM2, showing a negative correlation between these factors in the central and horizontal parafoveal areas of the ETDRS grid. info:eu-repo/grantAgreement/ES/DGA/B08-20R info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI20-00740 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.7 2022 PHARMACOLOGY & PHARMACY 68 / 278 = 0.245 2022 Q1 T1 BIOCHEMISTRY & MOLECULAR BIOLOGY 92 / 285 = 0.323 2022 Q2 T1 MEDICINE, RESEARCH & EXPERIMENTAL 54 / 136 = 0.397 2022 Q2 T2 0.897 2022 Medicine (miscellaneous) 2022 Q1 Biochemistry, Genetics and Molecular Biology (miscellaneous) 2022 Q2 3.7 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Orduna-Hospital, Elvira Universidad de Zaragoza (orcid)0000-0003-2710-1875 Boned-Murillo, Ana Diaz-Barreda, Maria Dolores Sanchez-Cano, Ana Universidad de Zaragoza (orcid)0000-0002-5621-1937 Sopeña-Pinilla, María Pinilla, Isabel Universidad de Zaragoza (orcid)0000-0003-0349-9997 1013 646 Universidad de Zaragoza Dpto. Cirugía Área Oftalmología 2002 647 Universidad de Zaragoza Dpto. Física Aplicada Área Óptica 10, 9 (2022), 2314 [10 pp.] Biomedicines 2227-9059 4627227 http://zaguan.unizar.es/record/119897/files/texto_completo.pdf Versión publicada 2791852 http://zaguan.unizar.es/record/119897/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:119897 articulos driver 2024-03-18-15:36:25 ARTICLE