000119936 001__ 119936
000119936 005__ 20240319081018.0
000119936 0247_ $$2doi$$a10.1080/2162402X.2022.2141973
000119936 0248_ $$2sideral$$a130598
000119936 037__ $$aART-2022-130598
000119936 041__ $$aeng
000119936 100__ $$aSerrano Del Valle, Alfonso
000119936 245__ $$aEcto-calreticulin expression in multiple myeloma correlates with a failed anti-tumoral immune response and bad prognosis
000119936 260__ $$c2022
000119936 5060_ $$aAccess copy available to the general public$$fUnrestricted
000119936 5203_ $$aImmunogenic cell death (ICD) has been proposed to be a crucial process for antitumor immunosurveillance. ICD is characterized by the exposure and emission of Damage Associated Molecular Patterns (DAMP), including calreticulin (CRT). A positive correlation between CRT exposure or total expression and improved anticancer immunosurveillance has been found in certain cancers, usually accompanied by favorable patient prognosis. In the present study, we sought to evaluate CRT levels in the plasma membrane of CD38+ bone marrow mononuclear cells (BMMCs) isolated from 71 patients with varying degrees of multiple myeloma (MM) disease and examine the possible relationship between basal CRT exposure and the bone marrow immune microenvironment, as well as its connection with different clinical markers. Data show that increased levels of cell surface-CRT were associated with more aggressive clinical features and with worse clinical prognosis in MM. High CRT expression in MM cells was associated with increased infiltration of NK cells, CD8+ T lymphocytes and dendritic cells (DC), indicative of an active anti-tumoral immune response, but also with a significantly higher presence of immunosuppressive Treg cells and increased expression of PD-L1 in myeloma cells.
000119936 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B31-20R$$9info:eu-repo/grantAgreement/ES/MCIN/AEI/10.13039/501100011033$$9info:eu-repo/grantAgreement/ES/MICINN/PID2019-105128RB-I00$$9info:eu-repo/grantAgreement/ES/MINECO/SAF2016-76338-R
000119936 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000119936 590__ $$a7.2$$b2022
000119936 592__ $$a2.003$$b2022
000119936 591__ $$aONCOLOGY$$b47 / 241 = 0.195$$c2022$$dQ1$$eT1
000119936 593__ $$aImmunology$$c2022$$dQ1
000119936 591__ $$aIMMUNOLOGY$$b37 / 161 = 0.23$$c2022$$dQ1$$eT1
000119936 593__ $$aOncology$$c2022$$dQ1
000119936 593__ $$aImmunology and Allergy$$c2022$$dQ1
000119936 594__ $$a12.5$$b2022
000119936 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000119936 700__ $$aBeltrán-Visiedo, Manuel$$uUniversidad de Zaragoza
000119936 700__ $$ade Poo-Rodríguez, Victoria
000119936 700__ $$aJiménez-Alduán, Nelia
000119936 700__ $$0(orcid)0000-0001-5068-7355$$aAzaceta, Gemma$$uUniversidad de Zaragoza
000119936 700__ $$aDíez, Rosana$$uUniversidad de Zaragoza
000119936 700__ $$aMartínez-Lázaro, Beatriz$$uUniversidad de Zaragoza
000119936 700__ $$aIzquierdo, Isabel$$uUniversidad de Zaragoza
000119936 700__ $$0(orcid)0000-0001-8515-3599$$aPalomera, Luis$$uUniversidad de Zaragoza
000119936 700__ $$0(orcid)0000-0003-2156-8378$$aNaval, Javier$$uUniversidad de Zaragoza
000119936 700__ $$0(orcid)0000-0002-5175-8394$$aAnel, Alberto$$uUniversidad de Zaragoza
000119936 700__ $$0(orcid)0000-0002-2315-9079$$aMarzo, Isabel$$uUniversidad de Zaragoza
000119936 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000119936 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000119936 7102_ $$11002$$2050$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Biología Celular
000119936 773__ $$g11, 1 (2022), e2141973 [10 pp.]$$pOncoimmunology$$tOncoImmunology$$x2162-4011
000119936 8564_ $$s2961019$$uhttps://zaguan.unizar.es/record/119936/files/texto_completo.pdf$$yVersión publicada
000119936 8564_ $$s1309064$$uhttps://zaguan.unizar.es/record/119936/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000119936 909CO $$ooai:zaguan.unizar.es:119936$$particulos$$pdriver
000119936 951__ $$a2024-03-18-15:53:51
000119936 980__ $$aARTICLE