119936 20240319081018.0 doi 10.1080/2162402X.2022.2141973 sideral 130598 ART-2022-130598 eng Serrano Del Valle, Alfonso Ecto-calreticulin expression in multiple myeloma correlates with a failed anti-tumoral immune response and bad prognosis 2022 Access copy available to the general public Unrestricted Immunogenic cell death (ICD) has been proposed to be a crucial process for antitumor immunosurveillance. ICD is characterized by the exposure and emission of Damage Associated Molecular Patterns (DAMP), including calreticulin (CRT). A positive correlation between CRT exposure or total expression and improved anticancer immunosurveillance has been found in certain cancers, usually accompanied by favorable patient prognosis. In the present study, we sought to evaluate CRT levels in the plasma membrane of CD38+ bone marrow mononuclear cells (BMMCs) isolated from 71 patients with varying degrees of multiple myeloma (MM) disease and examine the possible relationship between basal CRT exposure and the bone marrow immune microenvironment, as well as its connection with different clinical markers. Data show that increased levels of cell surface-CRT were associated with more aggressive clinical features and with worse clinical prognosis in MM. High CRT expression in MM cells was associated with increased infiltration of NK cells, CD8+ T lymphocytes and dendritic cells (DC), indicative of an active anti-tumoral immune response, but also with a significantly higher presence of immunosuppressive Treg cells and increased expression of PD-L1 in myeloma cells. info:eu-repo/grantAgreement/ES/DGA/B31-20R info:eu-repo/grantAgreement/ES/MCIN/AEI/10.13039/501100011033 info:eu-repo/grantAgreement/ES/MICINN/PID2019-105128RB-I00 info:eu-repo/grantAgreement/ES/MINECO/SAF2016-76338-R info:eu-repo/semantics/openAccess by-nc http://creativecommons.org/licenses/by-nc/3.0/es/ 7.2 2022 ONCOLOGY 47 / 241 = 0.195 2022 Q1 T1 IMMUNOLOGY 37 / 161 = 0.23 2022 Q1 T1 2.003 2022 Immunology 2022 Q1 Oncology 2022 Q1 Immunology and Allergy 2022 Q1 12.5 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Beltrán-Visiedo, Manuel Universidad de Zaragoza de Poo-Rodríguez, Victoria Jiménez-Alduán, Nelia Azaceta, Gemma Universidad de Zaragoza (orcid)0000-0001-5068-7355 Díez, Rosana Universidad de Zaragoza Martínez-Lázaro, Beatriz Universidad de Zaragoza Izquierdo, Isabel Universidad de Zaragoza Palomera, Luis Universidad de Zaragoza (orcid)0000-0001-8515-3599 Naval, Javier Universidad de Zaragoza (orcid)0000-0003-2156-8378 Anel, Alberto Universidad de Zaragoza (orcid)0000-0002-5175-8394 Marzo, Isabel Universidad de Zaragoza (orcid)0000-0002-2315-9079 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 1002 050 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Biología Celular 11, 1 (2022), e2141973 [10 pp.] Oncoimmunology OncoImmunology 2162-4011 2961019 http://zaguan.unizar.es/record/119936/files/texto_completo.pdf Versión publicada 1309064 http://zaguan.unizar.es/record/119936/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:119936 articulos driver 2024-03-18-15:53:51 ARTICLE