000119998 001__ 119998
000119998 005__ 20240319080946.0
000119998 0247_ $$2doi$$a10.1038/s41537-022-00309-w
000119998 0248_ $$2sideral$$a130929
000119998 037__ $$aART-2022-130929
000119998 041__ $$aeng
000119998 100__ $$aSolanes, Aleix
000119998 245__ $$aCombining MRI and clinical data to detect high relapse risk after the first episode of psychosis
000119998 260__ $$c2022
000119998 5060_ $$aAccess copy available to the general public$$fUnrestricted
000119998 5203_ $$aDetecting patients at high relapse risk after the first episode of psychosis (HRR-FEP) could help the clinician adjust the preventive treatment. To develop a tool to detect patients at HRR using their baseline clinical and structural MRI, we followed 227 patients with FEP for 18–24 months and applied MRIPredict. We previously optimized the MRI-based machine-learning parameters (combining unmodulated and modulated gray and white matter and using voxel-based ensemble) in two independent datasets. Patients estimated to be at HRR-FEP showed a substantially increased risk of relapse (hazard ratio = 4.58, P < 0.05). Accuracy was poorer when we only used clinical or MRI data. We thus show the potential of combining clinical and MRI data to detect which individuals are more likely to relapse, who may benefit from increased frequency of visits, and which are unlikely, who may be currently receiving unnecessary prophylactic treatments. We also provide an updated version of the MRIPredict software.
000119998 536__ $$9info:eu-repo/grantAgreement/EC/H2020/115916/EU/Psychiatric Ratings using Intermediate Stratified Markers/PRISM$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 115916-PRISM$$9info:eu-repo/grantAgreement/EC/H2020/777394/EU/Autism Innovative Medicine Studies – 2 – Trials/AIMS-2-TRIALS$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 777394-AIMS-2-TRIALS$$9info:eu-repo/grantAgreement/ES/MICIU-ISCIII-FEDER/PI08-0208$$9info:eu-repo/grantAgreement/ES/MICIU-ISCIII-FEDER/PI11-00325$$9info:eu-repo/grantAgreement/ES/MICIU-ISCIII-FEDER/PI14-00292$$9info:eu-repo/grantAgreement/ES/MICIU-ISCIII-FEDER/PI14-00612$$9info:eu-repo/grantAgreement/ES/MICIU-ISCIII-FEDER/PI14-01148$$9info:eu-repo/grantAgreement/ES/MICIU-ISCIII-FEDER/PI17-00481$$9info:eu-repo/grantAgreement/ES/MICIU-ISCIII-FEDER/PI17-01997$$9info:eu-repo/grantAgreement/ES/MICIU-ISCIII-FEDER/PI18-01055$$9info:eu-repo/grantAgreement/ES/MICIU-ISCIII-FEDER/PI19-00394$$9info:eu-repo/grantAgreement/ES/MICIU-ISCIII-FEDER/PI19-00766$$9info:eu-repo/grantAgreement/ES/MICIU-ISCIII-FEDER/PI20-00721$$9info:eu-repo/grantAgreement/ES/MICIU-ISCIII-FEDER/PI20-01342$$9info:eu-repo/grantAgreement/ES/MICIU-ISCIII-FEDER/PI21-00713$$9info:eu-repo/grantAgreement/ES/MICIU/ISCIII/PI14-01151
000119998 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000119998 590__ $$a0.0$$b2022
000119998 591__ $$aPSYCHIATRY
000119998 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000119998 700__ $$aMezquida, Gisela
000119998 700__ $$aJanssen, Joost
000119998 700__ $$aAmoretti, Silvia
000119998 700__ $$0(orcid)0000-0002-9098-655X$$aLobo, Antonio$$uUniversidad de Zaragoza
000119998 700__ $$aGonzález-Pinto, Ana
000119998 700__ $$aArango, Celso
000119998 700__ $$aVieta, Eduard
000119998 700__ $$aCastro-Fornieles, Josefina
000119998 700__ $$aBergé, Daniel
000119998 700__ $$aAlbacete, Auria
000119998 700__ $$aGiné, Eloi
000119998 700__ $$aParellada, Mara
000119998 700__ $$aBernardo, Miguel
000119998 700__ $$aBioque, Miquel
000119998 700__ $$aMorén, Constanza
000119998 700__ $$aPina-Camacho, Laura
000119998 700__ $$aDíaz-Caneja, Covadonga M.
000119998 700__ $$aZorrilla, Iñaki
000119998 700__ $$aCorres, Edurne Garcia
000119998 700__ $$aDe-La-Camara, Concepción
000119998 700__ $$aBarcones, Fe
000119998 700__ $$aEscarti, María José
000119998 700__ $$aAguilar, Eduardo Jesus
000119998 700__ $$aLegido, Teresa
000119998 700__ $$aMartin, Marta
000119998 700__ $$aVerdolini, Norma
000119998 700__ $$aMartinez-Aran, Anabel
000119998 700__ $$aBaeza, Immaculada
000119998 700__ $$ade la Serna, Elena
000119998 700__ $$aContreras, Fernando
000119998 700__ $$aBobes, Julio
000119998 700__ $$aGarcía-Portilla, María Paz
000119998 700__ $$aSanchez-Pastor, Luis
000119998 700__ $$aRodriguez-Jimenez, Roberto
000119998 700__ $$aUsall, Judith
000119998 700__ $$aButjosa, Anna
000119998 700__ $$aSalgado-Pineda, Pilar
000119998 700__ $$aSalvador, Raymond
000119998 700__ $$aPomarol-Clotet, Edith
000119998 700__ $$aRadua, Joaquim
000119998 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría
000119998 773__ $$g8, 1 (2022), 1-9$$pSchizophrenia (Lond.)$$tSchizophrenia$$x2754-6993
000119998 8564_ $$s795376$$uhttps://zaguan.unizar.es/record/119998/files/texto_completo.pdf$$yVersión publicada
000119998 8564_ $$s3320898$$uhttps://zaguan.unizar.es/record/119998/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000119998 909CO $$ooai:zaguan.unizar.es:119998$$particulos$$pdriver
000119998 951__ $$a2024-03-18-12:33:24
000119998 980__ $$aARTICLE