000120020 001__ 120020
000120020 005__ 20240319081003.0
000120020 0247_ $$2doi$$a10.1183/23120541.00121-2022
000120020 0248_ $$2sideral$$a130862
000120020 037__ $$aART-2022-130862
000120020 041__ $$aeng
000120020 100__ $$aHietakoste, S.
000120020 245__ $$aObstructive sleep apnoea-related respiratory events and desaturation severity are associated with the cardiac response
000120020 260__ $$c2022
000120020 5060_ $$aAccess copy available to the general public$$fUnrestricted
000120020 5203_ $$aObstructive sleep apnoea (OSA) causes, among other things, intermittent blood oxygen desaturations, increasing the sympathetic tone. Yet the effect of desaturations on heart rate variability (HRV), a simple and noninvasive method for assessing sympathovagal balance, has not been comprehensively studied. We aimed to study whether desaturation severity affects the immediate HRV.MethodsWe retrospectively analysed the electrocardiography signals in 5-min segments (n=39 132) recorded during clinical polysomnographies of 642 patients with suspected OSA. HRV parameters were calculated for each segment. The segments were pooled into severity groups based on the desaturation severity (i.e.the integrated area under the blood oxygen saturation curve) and the respiratory event rate within the segment. Covariate-adjusted regression analyses were performed to investigate possible confounding effects.ResultsWith increasing respiratory event rate, the normalised high-frequency band power (HFNU) decreased from 0.517 to 0.364 (p<0.01), the normalised low-frequency band power (LFNU) increased from 0.483 to 0.636 (p<0.01) and the mean RR interval decreased from 915 to 869 ms (p<0.01). Similarly, with increasing desaturation severity, the HFNUdecreased from 0.499 to 0.364 (p<0.01), the LFNUincreased from 0.501 to 0.636 (p<0.01) and the mean RR interval decreased from 952 to 854 ms (p<0.01). Desaturation severity-related findings were confirmed by considering the confounding factors in the regression analyses.ConclusionThe short-term HRV response differs based on the desaturation severity and the respiratory event rate in patients with suspected OSA. Therefore, a more detailed analysis of HRV and desaturation characteristics could enhance OSA severity estimation.
000120020 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FSE/T39-20R$$9info:eu-repo/grantAgreement/EC/H2020/965417/EU/Revolution of sleep diagnostics and personalized health care based on digital diagnostics and therapeutics with health data integration/SLEEP REVOLUTION$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 965417-SLEEP REVOLUTION
000120020 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000120020 590__ $$a4.6$$b2022
000120020 592__ $$a1.304$$b2022
000120020 591__ $$aRESPIRATORY SYSTEM$$b22 / 66 = 0.333$$c2022$$dQ2$$eT2
000120020 593__ $$aPulmonary and Respiratory Medicine$$c2022$$dQ1
000120020 594__ $$a5.2$$b2022
000120020 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000120020 700__ $$aKarhu, T.
000120020 700__ $$aSillanmäki, S.
000120020 700__ $$0(orcid)0000-0003-1272-0550$$aBailón, R.$$uUniversidad de Zaragoza
000120020 700__ $$aPenzel, T.
000120020 700__ $$aTöyräs, J.
000120020 700__ $$aLeppänen, T.
000120020 700__ $$aMyllymaa, S.
000120020 700__ $$aKainulainen, S.
000120020 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000120020 773__ $$g8, 4 (2022), 00121[12 pp.]$$pERJ open res.$$tERJ Open Research$$x2312-0541
000120020 8564_ $$s637647$$uhttps://zaguan.unizar.es/record/120020/files/texto_completo.pdf$$yVersión publicada
000120020 8564_ $$s2674302$$uhttps://zaguan.unizar.es/record/120020/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000120020 909CO $$ooai:zaguan.unizar.es:120020$$particulos$$pdriver
000120020 951__ $$a2024-03-18-14:20:55
000120020 980__ $$aARTICLE