120050 20240319081009.0 doi 10.1021/acs.jpcb.2c03300 sideral 130898 ART-2022-130898 eng Jurak, M. Characteristics of phospholipid–immunosuppressant–antioxidant mixed langmuir–blodgett films 2022 Access copy available to the general public Unrestricted Hemocompatibility is one of the major criteria for the successful cardiovascular applicability of novel biomaterials. In this context, monolayers of certain biomolecules can be used to improve surface biocompatibility. To this end, biocoatings incorporating a phospholipid (1,2-dioleoyl-sn-glycero-3-phosphocholine, DOPC), an immunosuppressant (cyclosporine A, CsA), and an antioxidant material (lauryl gallate, LG) were fabricated by depositing Langmuir films onto gold or mica substrates using the Langmuir–Blodgett (LB) technique. These LB monolayers were thoroughly characterized by means of quartz crystal microbalance (QCM), atomic force microscopy (AFM), cyclic voltammetry (CV), and contact angle (CA) measurements. The obtained results indicate that the properties of these LB films are modulated by the monolayer composition. The presence of LG in the three-component systems (DOPC–CsA–LG) increases the molecular packing and the surface coverage of the substrate, which affects the wettability of the biocoating. From the different compositions studied here, we conclude that DOPC–CsA–LG monolayers with a DOPC/CsA ratio of 1:1 and LG molar fractions of 0.50 and 0.75 exhibit improved surface biocompatible characteristics. These results open up new perspectives on our knowledge and better understanding of phenomena at the biomaterial/host interface. info:eu-repo/grantAgreement/ES/DGA/E31-20R info:eu-repo/grantAgreement/ES/DGA/LMP154-21 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 3.3 2022 CHEMISTRY, PHYSICAL 88 / 161 = 0.547 2022 Q3 T2 0.795 2022 Materials Chemistry 2022 Q1 Surfaces, Coatings and Films 2022 Q1 Physical and Theoretical Chemistry 2022 Q1 Medicine (miscellaneous) 2022 Q2 5.6 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Szafran, K. Cea, P. Universidad de Zaragoza (orcid)0000-0002-4729-9578 Martín, S. Universidad de Zaragoza (orcid)0000-0001-9193-3874 2012 755 Universidad de Zaragoza Dpto. Química Física Área Química Física 126, 36 (2022), 6936-6947 J. phys. chem., B Journal of physical chemistry. B 1520-6106 5838744 http://zaguan.unizar.es/record/120050/files/texto_completo.pdf Versión publicada 3078359 http://zaguan.unizar.es/record/120050/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:120050 articulos driver 2024-03-18-14:56:52 ARTICLE