doi:10.3390/ijerph191811384engHernández-Vicente, A.Marín Puyalto, J.Pueyo, E.Vicente Rodríguez, G.Garatachea, N.Physical activity in centenarians beyond cut-point-based accelerometer metricsART-2022-130833This study described and compared physical activity (PA) characteristics at the end of the human lifespan using conventional cut-point-based versus cut-point-free accelerometer metrics. Eighteen institutionalized centenarians (101.5 ± 2.1 years, 72.2% female, 89% frail) wore the wrist GENEActiv accelerometer for 7 days. Conventional metrics, such as time spent in light-intensity PA (LiPA) and moderate-to-vigorous intensity PA (MVPA) were calculated according to published cut-points for adults and older adults. The following cut-point-free metrics were evaluated: average acceleration, intensity gradient and Mx metrics. Depending on the cut-point, centenarians accumulated a median of 15–132 min/day of LiPA and 3–15 min/day of MVPA. The average acceleration was 9.2 mg [Q1: 6.7 mg–Q3: 12.6 mg] and the intensity gradient was −3.19 [−3.34–−3.12]. The distribution of Z-values revealed positive skew for MVPA, indicating a potential floor effect, whereas the skew magnitude was attenuated for cut-point-free metrics such as intensity gradient or M5. However, both cut-point-based and cut-point-free metrics were similarly positively associated with functional independence, cognitive and physical capacities. This is the first time that PA has been described in centenarians using cut-point-free metrics. Our results suggest that new analytical approaches could overcome cut-point limitations when studying the oldest-old. Future studies using these new cut-point-free PA metrics are warranted to provide more complete and comparable information across groups and populations.2022http://zaguan.unizar.es/record/12009610.3390/ijerph191811384http://zaguan.unizar.es/record/120096oai:zaguan.unizar.es:120096info:eu-repo/grantAgreement/ES/DGA-FSE/T39-20Rinfo:eu-repo/grantAgreement/ES/DGA/LMP 24-18info:eu-repo/grantAgreement/ES/DGA/LMP 94-21info:eu-repo/grantAgreement/EC/H2020/638284/EU/Is your heart aging well? A systems biology approach to characterize cardiac aging from the cell to the body surface/MODELAGEThis project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 638284-MODELAGEinfo:eu-repo/grantAgreement/ES/MECD/FPU16-05879info:eu-repo/grantAgreement/ES/MICIU/PID2019-105674RB-I00info:eu-repo/grantAgreement/ES/MINECO/DEP2016-78309-Rinfo:eu-repo/grantAgreement/ES/UZ/UZ2021-BIO-05International journal of environmental research and public health 19, 18 (2022), 11384[13 pp.]byhttp://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccess