000120105 001__ 120105 000120105 005__ 20240319081022.0 000120105 0247_ $$2doi$$a10.1186/s13063-022-06551-y 000120105 0248_ $$2sideral$$a130381 000120105 037__ $$aART-2022-130381 000120105 041__ $$aeng 000120105 100__ $$aTimulak, Ladislav 000120105 245__ $$aEffectiveness of the internet-based Unified Protocol transdiagnostic intervention for the treatment of depression, anxiety and related disorders in a primary care setting: a randomized controlled trial 000120105 260__ $$c2022 000120105 5060_ $$aAccess copy available to the general public$$fUnrestricted 000120105 5203_ $$aBackground Research has shown that internet-based cognitive behavioural therapy (iCBT) can be a very promising solution to increase access to and the dissemination of evidence-based treatments to all of the population in need. However, iCBT is still underutilized in clinical contexts, such as primary care. In order to achieve the effective implementation of these protocols, more studies in ecological settings are needed. The Unified Protocol (UP) is a transdiagnostic CBT protocol for the treatment of emotional disorders, which includes depression, anxiety and related disorders, that has shown its efficacy across different contexts and populations. An internet-based UP (iUP) programme has recently been developed as an emerging internet-based treatment for emotional disorders. However, the internet-delivered version of the UP (iUP) has not yet been examined empirically. The current project seeks to analyse the effectiveness of the iUP as a treatment for depression, anxiety and related emotional disorders in a primary care public health setting. Methods The current study will employ a parallel-group, randomized controlled trial design. Participants will be randomly assigned to (a) the internet-based Unified Protocol (iUP), or (b) enhanced waiting list control (eWLC). Randomization will follow a 2:1 allocation ratio, with sample size calculations suggesting a required sample of 120 (iUP=80; eWLC=40). The Mini-International Neuropsychiatric Interview (M.I.N.I.) will be used for assessing potential participants. The Overall Anxiety Severity and Impairment Scale (OASIS) and the Overall Depression Severity and Impairment Scale (ODSIS) as well as other standardized questionnaires will be used for assessments at baseline, 4 weeks, 8 weeks and 12 weeks from baseline and for the iUP condition during the follow-up. Discussion Combining the advantages of a transdiagnostic treatment with an online delivery format may have the potential to significantly lower the burden of emotional disorders in public health primary care setting. Anxiety and depression, often comorbid, are the most prevalent psychological disorders in primary care. Because the iUP allows for the treatment of different disorders and comorbidity, this treatment could represent an adequate choice for patients that demand mental health care in a primary care setting. 000120105 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000120105 590__ $$a2.5$$b2022 000120105 592__ $$a0.814$$b2022 000120105 591__ $$aMEDICINE, RESEARCH & EXPERIMENTAL$$b99 / 136 = 0.728$$c2022$$dQ3$$eT3 000120105 593__ $$aPharmacology (medical)$$c2022$$dQ2 000120105 593__ $$aMedicine (miscellaneous)$$c2022$$dQ2 000120105 594__ $$a3.6$$b2022 000120105 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000120105 700__ $$aRichards, Derek 000120105 700__ $$aBhandal-Griffin, Louise 000120105 700__ $$aHealy, Patrick 000120105 700__ $$aAzevedo, Juliana 000120105 700__ $$aConnon, Graham 000120105 700__ $$aMartin, Elaine 000120105 700__ $$aKearney, Aoife 000120105 700__ $$aO’Kelly, Conor 000120105 700__ $$aEnrique, Angel 000120105 700__ $$aEilert, Nora 000120105 700__ $$aO’Brien, Sorcha 000120105 700__ $$aHarty, Siobhan 000120105 700__ $$0(orcid)0000-0002-3749-3756$$aGonzález-Robles, Alberto$$uUniversidad de Zaragoza 000120105 700__ $$aEustis, Elizabeth H. 000120105 700__ $$aBarlow, David H. 000120105 700__ $$aFarchione, Todd J. 000120105 7102_ $$14009$$2680$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Person.Eval.Trat.Psicoló. 000120105 773__ $$g23, 1 (2022), 721 [11 pp.]$$pTrials$$tTrials$$x1745-6215 000120105 8564_ $$s1377010$$uhttps://zaguan.unizar.es/record/120105/files/texto_completo.pdf$$yVersión publicada 000120105 8564_ $$s2356187$$uhttps://zaguan.unizar.es/record/120105/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000120105 909CO $$ooai:zaguan.unizar.es:120105$$particulos$$pdriver 000120105 951__ $$a2024-03-18-16:17:32 000120105 980__ $$aARTICLE