000120116 001__ 120116 000120116 005__ 20240319081022.0 000120116 0247_ $$2doi$$a10.1093/cvr/cvac157.101 000120116 0248_ $$2sideral$$a130998 000120116 037__ $$aART-2022-130998 000120116 041__ $$aeng 000120116 100__ $$aRuiz Muñoz, Aroa 000120116 245__ $$aOral Presentation No. 121. Aortic stiffness descriptors by cardiac magnetic resonance are correlated with mechanical testing of ex-vivo aortic aneurysms specimens 000120116 260__ $$c2022 000120116 5060_ $$aAccess copy available to the general public$$fUnrestricted 000120116 5203_ $$aBackground Aortic stiffness independently predicts mayor adverse cardiovascular events and mortality in the general population. Cardiovascular magnetic resonance (CMR) permits the assessment of a number of parameters theoretically linked to aortic stiffness, such as distensibility (AD), pulse wave velocity (PWV) and proximal aorta longitudinal strain. However, no previous study validates these parameters as descriptors of aortic wall stiffness against ex-vivo mechanical testing. Materials and methods Ascending aorta (AAo) specimens were collected from 20 patients undergoing AAo replacement for aneurysms. Patients underwent a CMR protocol in the days leading to the surgery, including 4D flow CMR. Two 15×5 mm specimens (one oriented in the circumferential and the other in the longitudinal aortic direction) were extracted during surgery, and later tested controlling for extension force. Elongation was measured by laser video extensometer and the tangent of the stress-strain curve at diastolic pressure was extracted. AAo PWV and the Eh product (E being Young modulus and h wall thickness) were measured from 4D flow CMR while AD and AAo longitudinal were quantified from cine images. Results and conclusions Marked correlations were found between circumferential elastic modulus and AAo AD (R = −0.502), PWV(R = 0.652) and Eh (R = 0.602). Similarly, strong correlation was identified between AAo longitudinal strain and longitudinal elastic modulus(R = −0.513). In conclusion, PWV and the Eh product are positively related to aortic wall stiffness while aortic distensibility and strain show negative relationships. Thus, these biomarkers are a reliable expression of aortic wall stiffness. 000120116 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/ 000120116 590__ $$a10.9$$b2022 000120116 592__ $$a2.481$$b2022 000120116 591__ $$aCARDIAC & CARDIOVASCULAR SYSTEMS$$b12 / 143 = 0.084$$c2022$$dQ1$$eT1 000120116 593__ $$aCardiology and Cardiovascular Medicine$$c2022$$dQ1 000120116 593__ $$aPhysiology (medical)$$c2022$$dQ1 000120116 593__ $$aPhysiology$$c2022$$dQ1 000120116 594__ $$a18.3$$b2022 000120116 655_4 $$ainfo:eu-repo/semantics/conferenceObject$$vinfo:eu-repo/semantics/publishedVersion 000120116 700__ $$aGuala, Andrea 000120116 700__ $$0(orcid)0000-0002-8503-9291$$aCilla, Myriam$$uUniversidad de Zaragoza 000120116 700__ $$0(orcid)0000-0002-8375-0354$$aMartínez, Miguel$$uUniversidad de Zaragoza 000120116 700__ $$aDux-Santoy, Lydia 000120116 700__ $$aTeixidó-Turà, Gisela 000120116 700__ $$aGarrido-Oliver, Juan 000120116 700__ $$aGalian, Laura 000120116 700__ $$aSao-Aviles, Augusto 000120116 700__ $$aEvangelista, Arturo 000120116 700__ $$aFerreira-Gonzalez, Ignacio 000120116 700__ $$0(orcid)0000-0002-0664-5024$$aPeña, Estefania$$uUniversidad de Zaragoza 000120116 700__ $$aRodriguez-Palomares, Jose 000120116 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est. 000120116 773__ $$g118, Supplement_2 (2022), [1 pp.]$$pCardiovasc. Res.$$tCardiovascular research$$x0008-6363 000120116 8564_ $$s56942$$uhttps://zaguan.unizar.es/record/120116/files/texto_completo.pdf$$yVersión publicada 000120116 8564_ $$s1374086$$uhttps://zaguan.unizar.es/record/120116/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000120116 909CO $$ooai:zaguan.unizar.es:120116$$particulos$$pdriver 000120116 951__ $$a2024-03-18-16:19:32 000120116 980__ $$aARTICLE