000120142 001__ 120142
000120142 005__ 20240319081002.0
000120142 0247_ $$2doi$$a10.3390/jcm11237163
000120142 0248_ $$2sideral$$a131032
000120142 037__ $$aART-2022-131032
000120142 041__ $$aeng
000120142 100__ $$aSiddi, Sara
000120142 245__ $$aBiopsychosocial response to the COVID-19 lockdown in people with major depressive disorder and multiple sclerosis
000120142 260__ $$c2022
000120142 5060_ $$aAccess copy available to the general public$$fUnrestricted
000120142 5203_ $$aBackground: Changes in lifestyle, finances and work status during COVID-19 lockdowns may have led to biopsychosocial changes in people with pre-existing vulnerabilities such as Major Depressive Disorders (MDDs) and Multiple Sclerosis (MS). Methods: Data were collected as a part of the RADAR-CNS (Remote Assessment of Disease and Relapse—Central Nervous System) program. We analyzed the following data from long-term participants in a decentralized multinational study: symptoms of depression, heart rate (HR) during the day and night; social activity; sedentary state, steps and physical activity of varying intensity. Linear mixed-effects regression analyses with repeated measures were fitted to assess the changes among three time periods (pre, during and post-lockdown) across the groups, adjusting for depression severity before the pandemic and gender. Results: Participants with MDDs (N = 255) and MS (N = 214) were included in the analyses. Overall, depressive symptoms remained stable across the three periods in both groups. A lower mean HR and HR variation were observed between pre and during lockdown during the day for MDDs and during the night for MS. HR variation during rest periods also decreased between pre- and post-lockdown in both clinical conditions. We observed a reduction in physical activity for MDDs and MS upon the introduction of lockdowns. The group with MDDs exhibited a net increase in social interaction via social network apps over the three periods. Conclusions: Behavioral responses to the lockdown measured by social activity, physical activity and HR may reflect changes in stress in people with MDDs and MS. Remote technology monitoring might promptly activate an early warning of physical and social alterations in these stressful situations. Future studies must explore how stress does or does not impact depression severity.
000120142 536__ $$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 Innovative Medicines Initiative 2 (IMI2)$$9info:eu-repo/grantAgreement/EUR/H2020/Innovative Medicines Initiative 2 (IMI2)$$9info:eu-repo/grantAgreement/EC/H2020/115902/EU/Remote Assessment of Disease and Relapse in Central Nervous System Disorders/RADAR-CNS$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 115902-RADAR-CNS
000120142 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000120142 590__ $$a3.9$$b2022
000120142 592__ $$a0.935$$b2022
000120142 591__ $$aMEDICINE, GENERAL & INTERNAL$$b58 / 169 = 0.343$$c2022$$dQ2$$eT2
000120142 593__ $$aMedicine (miscellaneous)$$c2022$$dQ1
000120142 594__ $$a5.4$$b2022
000120142 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000120142 700__ $$aGiné Vázquez, Iago
000120142 700__ $$0(orcid)0000-0003-1272-0550$$aBailon, Raquel$$uUniversidad de Zaragoza
000120142 700__ $$aMatcham, Faith
000120142 700__ $$aLamers, Femke
000120142 700__ $$0(orcid)0000-0002-1297-0691$$aKontaxis, Spyridon$$uUniversidad de Zaragoza
000120142 700__ $$aLaporta, Estela
000120142 700__ $$aGarcia, Esther
000120142 700__ $$aArranz, Belen
000120142 700__ $$aDalla Costa, Gloria
000120142 700__ $$aGuerrero, Ana Isabel
000120142 700__ $$aZabalza, Ana
000120142 700__ $$aBuron, Mathias Due
000120142 700__ $$aComi, Giancarlo
000120142 700__ $$aLeocani, Letizia
000120142 700__ $$aAnnas, Peter
000120142 700__ $$aHotopf, Matthew
000120142 700__ $$aPenninx, Brenda W. J. H.
000120142 700__ $$aMagyari, Melinda
000120142 700__ $$aSørensen, Per S.
000120142 700__ $$aMontalban, Xavier
000120142 700__ $$aLavelle, Grace
000120142 700__ $$aIvan, Alina
000120142 700__ $$aOetzmann, Carolin
000120142 700__ $$aWhite, Katie M.
000120142 700__ $$aDifrancesco, Sonia
000120142 700__ $$aLocatelli, Patrick
000120142 700__ $$aMohr, David C.
000120142 700__ $$aAguiló, Jordi
000120142 700__ $$aNarayan, Vaibhav
000120142 700__ $$aFolarin, Amos
000120142 700__ $$aDobson, Richard J. B.
000120142 700__ $$aDineley, Judith
000120142 700__ $$aLeightley, Daniel
000120142 700__ $$aCummins, Nicholas
000120142 700__ $$aVairavan, Srinivasan
000120142 700__ $$aRanjan, Yathart
000120142 700__ $$aRashid, Zulqarnain
000120142 700__ $$aRintala, Aki
000120142 700__ $$aGirolamo, Giovanni De
000120142 700__ $$aPreti, Antonio
000120142 700__ $$aSimblett, Sara
000120142 700__ $$aWykes, Til
000120142 700__ $$aMyin-Germeys, Inez
000120142 700__ $$aHaro, Josep Maria
000120142 700__ $$a
000120142 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000120142 773__ $$g11, 23 (2022), 7163 [20 pp.]$$pJ. clin.med.$$tJournal of Clinical Medicine$$x2077-0383
000120142 8564_ $$s2542032$$uhttps://zaguan.unizar.es/record/120142/files/texto_completo.pdf$$yVersión publicada
000120142 8564_ $$s2812252$$uhttps://zaguan.unizar.es/record/120142/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000120142 909CO $$ooai:zaguan.unizar.es:120142$$particulos$$pdriver
000120142 951__ $$a2024-03-18-14:16:29
000120142 980__ $$aARTICLE