120142 20240319081002.0 doi 10.3390/jcm11237163 sideral 131032 ART-2022-131032 eng Siddi, Sara Biopsychosocial response to the COVID-19 lockdown in people with major depressive disorder and multiple sclerosis 2022 Access copy available to the general public Unrestricted Background: Changes in lifestyle, finances and work status during COVID-19 lockdowns may have led to biopsychosocial changes in people with pre-existing vulnerabilities such as Major Depressive Disorders (MDDs) and Multiple Sclerosis (MS). Methods: Data were collected as a part of the RADAR-CNS (Remote Assessment of Disease and Relapse—Central Nervous System) program. We analyzed the following data from long-term participants in a decentralized multinational study: symptoms of depression, heart rate (HR) during the day and night; social activity; sedentary state, steps and physical activity of varying intensity. Linear mixed-effects regression analyses with repeated measures were fitted to assess the changes among three time periods (pre, during and post-lockdown) across the groups, adjusting for depression severity before the pandemic and gender. Results: Participants with MDDs (N = 255) and MS (N = 214) were included in the analyses. Overall, depressive symptoms remained stable across the three periods in both groups. A lower mean HR and HR variation were observed between pre and during lockdown during the day for MDDs and during the night for MS. HR variation during rest periods also decreased between pre- and post-lockdown in both clinical conditions. We observed a reduction in physical activity for MDDs and MS upon the introduction of lockdowns. The group with MDDs exhibited a net increase in social interaction via social network apps over the three periods. Conclusions: Behavioral responses to the lockdown measured by social activity, physical activity and HR may reflect changes in stress in people with MDDs and MS. Remote technology monitoring might promptly activate an early warning of physical and social alterations in these stressful situations. Future studies must explore how stress does or does not impact depression severity. info:eu-repo/grantAgreement/EUR/H2020/Innovative Medicines Initiative 2 (IMI2) This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 Innovative Medicines Initiative 2 (IMI2) info:eu-repo/grantAgreement/EC/H2020/115902/EU/Remote Assessment of Disease and Relapse in Central Nervous System Disorders/RADAR-CNS This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 115902-RADAR-CNS info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 3.9 2022 MEDICINE, GENERAL & INTERNAL 58 / 169 = 0.343 2022 Q2 T2 0.935 2022 Medicine (miscellaneous) 2022 Q1 5.4 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Giné Vázquez, Iago Bailon, Raquel Universidad de Zaragoza (orcid)0000-0003-1272-0550 Matcham, Faith Lamers, Femke Kontaxis, Spyridon Universidad de Zaragoza (orcid)0000-0002-1297-0691 Laporta, Estela Garcia, Esther Arranz, Belen Dalla Costa, Gloria Guerrero, Ana Isabel Zabalza, Ana Buron, Mathias Due Comi, Giancarlo Leocani, Letizia Annas, Peter Hotopf, Matthew Penninx, Brenda W. J. H. Magyari, Melinda Sørensen, Per S. Montalban, Xavier Lavelle, Grace Ivan, Alina Oetzmann, Carolin White, Katie M. Difrancesco, Sonia Locatelli, Patrick Mohr, David C. Aguiló, Jordi Narayan, Vaibhav Folarin, Amos Dobson, Richard J. B. Dineley, Judith Leightley, Daniel Cummins, Nicholas Vairavan, Srinivasan Ranjan, Yathart Rashid, Zulqarnain Rintala, Aki Girolamo, Giovanni De Preti, Antonio Simblett, Sara Wykes, Til Myin-Germeys, Inez Haro, Josep Maria 5008 800 Universidad de Zaragoza Dpto. Ingeniería Electrón.Com. Área Teoría Señal y Comunicac. 11, 23 (2022), 7163 [20 pp.] J. clin.med. Journal of Clinical Medicine 2077-0383 2542032 http://zaguan.unizar.es/record/120142/files/texto_completo.pdf Versión publicada 2812252 http://zaguan.unizar.es/record/120142/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:120142 articulos driver 2024-03-18-14:16:29 ARTICLE