000120153 001__ 120153
000120153 005__ 20240319081003.0
000120153 0247_ $$2doi$$a10.3390/jpm12111807
000120153 0248_ $$2sideral$$a131030
000120153 037__ $$aART-2022-131030
000120153 041__ $$aeng
000120153 100__ $$0(orcid)0000-0003-2710-1875$$aOrduna-Hospital, Elvira$$uUniversidad de Zaragoza
000120153 245__ $$aSpeckle Contrast as Retinal Tissue Integrity Biomarker in Patients with Type 1 Diabetes Mellitus with No Retinopathy
000120153 260__ $$c2022
000120153 5060_ $$aAccess copy available to the general public$$fUnrestricted
000120153 5203_ $$aPurpose: To study the retinal and choroidal layers in type 1 diabetes mellitus (DM1) without diabetic retinopathy (DR), using speckle contrast of optical coherence tomography (OCT) images as a tissue biomarker in comparison with healthy subjects. Methods: OCT Spectralis images of 148 eyes, 84 from DM1 patients without DR signs, and 64 belonging to the control group, were collected. The speckle contrast and thickness of the inner retinal layer (IRL), the outer retinal layer (ORL), and the choroidal layer in the nasal parafoveal area (N3), were prospectively analyzed. Results: A statistically significant difference (p = 0.001) in the IRL thickness between groups was observed, being thicker in the DM1 group. There were no differences in the ORL and choroidal thicknesses between groups. A statistically significant difference (p = 0.02) in the IRL speckle contrast was obtained, being lower in the DM1 group. The maximum speckle contrast was reached in the ORL for both groups, although in the DM1 group, it occurs closer to the choroid, at 64 ± 8 μm (p = 0.008). Conclusions: Statistically significant differences were found in speckle contrast and thickness between the control and the DM1 group, suggesting an IRL alteration of DM1 patients, supporting the retinal neurodegeneration before DR signs are observed.
000120153 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B08-20R$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI20-00740
000120153 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000120153 590__ $$a3.4$$b2022
000120153 592__ $$a0.665$$b2022
000120153 591__ $$aMEDICINE, GENERAL & INTERNAL$$b67 / 169 = 0.396$$c2022$$dQ2$$eT2
000120153 593__ $$aMedicine (miscellaneous)$$c2022$$dQ2
000120153 591__ $$aHEALTH CARE SCIENCES & SERVICES$$b42 / 106 = 0.396$$c2022$$dQ2$$eT2
000120153 594__ $$a2.6$$b2022
000120153 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000120153 700__ $$aArcas-Carbonell, Maria
000120153 700__ $$0(orcid)0000-0002-5621-1937$$aSanchez-Cano, Ana$$uUniversidad de Zaragoza
000120153 700__ $$0(orcid)0000-0003-0349-9997$$aPinilla, Isabel$$uUniversidad de Zaragoza
000120153 700__ $$0(orcid)0000-0001-5186-1837$$aConsejo, Alejandra$$uUniversidad de Zaragoza
000120153 7102_ $$12002$$2385$$aUniversidad de Zaragoza$$bDpto. Física Aplicada$$cÁrea Física Aplicada
000120153 7102_ $$11013$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Oftalmología
000120153 7102_ $$12002$$2647$$aUniversidad de Zaragoza$$bDpto. Física Aplicada$$cÁrea Óptica
000120153 773__ $$g12, 11 (2022), 1807 [10 pp.]$$pJ. pers. med.$$tJournal of Personalized Medicine$$x2075-4426
000120153 8564_ $$s1695146$$uhttps://zaguan.unizar.es/record/120153/files/texto_completo.pdf$$yVersión publicada
000120153 8564_ $$s2728620$$uhttps://zaguan.unizar.es/record/120153/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000120153 909CO $$ooai:zaguan.unizar.es:120153$$particulos$$pdriver
000120153 951__ $$a2024-03-18-14:21:37
000120153 980__ $$aARTICLE