120153 20240319081003.0 doi 10.3390/jpm12111807 sideral 131030 ART-2022-131030 eng Orduna-Hospital, Elvira Universidad de Zaragoza (orcid)0000-0003-2710-1875 Speckle Contrast as Retinal Tissue Integrity Biomarker in Patients with Type 1 Diabetes Mellitus with No Retinopathy 2022 Access copy available to the general public Unrestricted Purpose: To study the retinal and choroidal layers in type 1 diabetes mellitus (DM1) without diabetic retinopathy (DR), using speckle contrast of optical coherence tomography (OCT) images as a tissue biomarker in comparison with healthy subjects. Methods: OCT Spectralis images of 148 eyes, 84 from DM1 patients without DR signs, and 64 belonging to the control group, were collected. The speckle contrast and thickness of the inner retinal layer (IRL), the outer retinal layer (ORL), and the choroidal layer in the nasal parafoveal area (N3), were prospectively analyzed. Results: A statistically significant difference (p = 0.001) in the IRL thickness between groups was observed, being thicker in the DM1 group. There were no differences in the ORL and choroidal thicknesses between groups. A statistically significant difference (p = 0.02) in the IRL speckle contrast was obtained, being lower in the DM1 group. The maximum speckle contrast was reached in the ORL for both groups, although in the DM1 group, it occurs closer to the choroid, at 64 ± 8 μm (p = 0.008). Conclusions: Statistically significant differences were found in speckle contrast and thickness between the control and the DM1 group, suggesting an IRL alteration of DM1 patients, supporting the retinal neurodegeneration before DR signs are observed. info:eu-repo/grantAgreement/ES/DGA/B08-20R info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI20-00740 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 3.4 2022 MEDICINE, GENERAL & INTERNAL 67 / 169 = 0.396 2022 Q2 T2 HEALTH CARE SCIENCES & SERVICES 42 / 106 = 0.396 2022 Q2 T2 0.665 2022 Medicine (miscellaneous) 2022 Q2 2.6 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Arcas-Carbonell, Maria Sanchez-Cano, Ana Universidad de Zaragoza (orcid)0000-0002-5621-1937 Pinilla, Isabel Universidad de Zaragoza (orcid)0000-0003-0349-9997 Consejo, Alejandra Universidad de Zaragoza (orcid)0000-0001-5186-1837 2002 385 Universidad de Zaragoza Dpto. Física Aplicada Área Física Aplicada 1013 646 Universidad de Zaragoza Dpto. Cirugía Área Oftalmología 2002 647 Universidad de Zaragoza Dpto. Física Aplicada Área Óptica 12, 11 (2022), 1807 [10 pp.] J. pers. med. Journal of Personalized Medicine 2075-4426 1695146 http://zaguan.unizar.es/record/120153/files/texto_completo.pdf Versión publicada 2728620 http://zaguan.unizar.es/record/120153/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:120153 articulos driver 2024-03-18-14:21:37 ARTICLE