000120157 001__ 120157
000120157 005__ 20240319081006.0
000120157 0247_ $$2doi$$a10.3390/antiox11122381
000120157 0248_ $$2sideral$$a131034
000120157 037__ $$aART-2022-131034
000120157 041__ $$aeng
000120157 100__ $$aPaesa, Mónica$$uUniversidad de Zaragoza
000120157 245__ $$aAnti-inflammatory and chondroprotective effects induced by phenolic compounds from onion waste extracts in ATDC-5 chondrogenic cell line
000120157 260__ $$c2022
000120157 5060_ $$aAccess copy available to the general public$$fUnrestricted
000120157 5203_ $$aOsteoarthritis is a prevalent degenerative condition that is closely related to the destruction and inflammation of cartilage. The high prevalence of this pathology exhorts researchers to search for novel therapeutic approaches. Vegetable–fruit wastes have emerged as a promising origin of anti-inflammatory and antioxidant compounds that, in some cases, may also exert chondroprotective effects. This study aims to decipher the potential of onion waste products in the inhibition of molecular events involved in osteoarthritis. Onion extracts showed a high content of phenolic compounds and antioxidant properties. Cytocompatibility was demonstrated in the chondrogenic cell line ATDC-5, exerting viability percentages higher than 90% and a slight increase in the S phase cycle cell. The induction of inflammation mediated by the lipopolysaccharide and onion extracts’ treatment substantially inhibited molecular markers related to inflammation and cartilage degradation, highlighting the promising application of onion extracts in biomedical approaches. The in silico analyses suggested that the results could be attributed to protocatechuic, ellagic, and vanillic acids’ greater cell membrane permeability. Our work provides distinctive information about the possible application of waste onion extracts as functional components with anti-inflammatory and chondroprotective characteristics in osteoarthritis.
000120157 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B16-20R$$9info:eu-repo/grantAgreement/EC/H2020/801586/EU/International Doctoral Programme for Talent Attraction to the Campus of International Excellence of the Ebro Valley/IberusTalent$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 801586-IberusTalent$$9info:eu-repo/grantAgreement/ES/ISCIII/MS19-00092$$9info:eu-repo/grantAgreement/ES/MICINN-ISCIIII-FEDER/PID2019-104915RB-I00$$9info:eu-repo/grantAgreement/EUR/SUDOE/INTERREG/Redvalue-SOE1-PI-E0123
000120157 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000120157 590__ $$a7.0$$b2022
000120157 592__ $$a1.084$$b2022
000120157 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b46 / 285 = 0.161$$c2022$$dQ1$$eT1
000120157 593__ $$aBiochemistry$$c2022$$dQ1
000120157 591__ $$aFOOD SCIENCE & TECHNOLOGY$$b13 / 142 = 0.092$$c2022$$dQ1$$eT1
000120157 593__ $$aClinical Biochemistry$$c2022$$dQ1
000120157 591__ $$aCHEMISTRY, MEDICINAL$$b6 / 60 = 0.1$$c2022$$dQ1$$eT1
000120157 593__ $$aFood Science$$c2022$$dQ1
000120157 593__ $$aPhysiology$$c2022$$dQ1
000120157 593__ $$aMolecular Biology$$c2022$$dQ2
000120157 593__ $$aCell Biology$$c2022$$dQ2
000120157 594__ $$a8.8$$b2022
000120157 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000120157 700__ $$aAncín-Azpilicueta, Carmen
000120157 700__ $$aVelderrain-Rodríguez, Gustavo
000120157 700__ $$aMartin-Belloso, Olga
000120157 700__ $$aGualillo, Oreste
000120157 700__ $$0(orcid)0000-0002-8251-8457$$aOsada, Jesús$$uUniversidad de Zaragoza
000120157 700__ $$0(orcid)0000-0002-3595-7668$$aRodríguez-Yoldi, Maria Jesús$$uUniversidad de Zaragoza
000120157 700__ $$0(orcid)0000-0003-2293-363X$$aMendoza, Gracia
000120157 7102_ $$11012$$2410$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Fisiología
000120157 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000120157 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000120157 773__ $$g11, 12 (2022), 2381 [14 pp.]$$pAntioxidants$$tAntioxidants$$x2076-3921
000120157 8564_ $$s1440359$$uhttps://zaguan.unizar.es/record/120157/files/texto_completo.pdf$$yVersión publicada
000120157 8564_ $$s2694310$$uhttps://zaguan.unizar.es/record/120157/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000120157 909CO $$ooai:zaguan.unizar.es:120157$$particulos$$pdriver
000120157 951__ $$a2024-03-18-14:38:31
000120157 980__ $$aARTICLE