120157 20240319081006.0 doi 10.3390/antiox11122381 sideral 131034 ART-2022-131034 eng Paesa, Mónica Universidad de Zaragoza Anti-inflammatory and chondroprotective effects induced by phenolic compounds from onion waste extracts in ATDC-5 chondrogenic cell line 2022 Access copy available to the general public Unrestricted Osteoarthritis is a prevalent degenerative condition that is closely related to the destruction and inflammation of cartilage. The high prevalence of this pathology exhorts researchers to search for novel therapeutic approaches. Vegetable–fruit wastes have emerged as a promising origin of anti-inflammatory and antioxidant compounds that, in some cases, may also exert chondroprotective effects. This study aims to decipher the potential of onion waste products in the inhibition of molecular events involved in osteoarthritis. Onion extracts showed a high content of phenolic compounds and antioxidant properties. Cytocompatibility was demonstrated in the chondrogenic cell line ATDC-5, exerting viability percentages higher than 90% and a slight increase in the S phase cycle cell. The induction of inflammation mediated by the lipopolysaccharide and onion extracts’ treatment substantially inhibited molecular markers related to inflammation and cartilage degradation, highlighting the promising application of onion extracts in biomedical approaches. The in silico analyses suggested that the results could be attributed to protocatechuic, ellagic, and vanillic acids’ greater cell membrane permeability. Our work provides distinctive information about the possible application of waste onion extracts as functional components with anti-inflammatory and chondroprotective characteristics in osteoarthritis. info:eu-repo/grantAgreement/ES/DGA/B16-20R info:eu-repo/grantAgreement/EC/H2020/801586/EU/International Doctoral Programme for Talent Attraction to the Campus of International Excellence of the Ebro Valley/IberusTalent This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 801586-IberusTalent info:eu-repo/grantAgreement/ES/ISCIII/MS19-00092 info:eu-repo/grantAgreement/ES/MICINN-ISCIIII-FEDER/PID2019-104915RB-I00 info:eu-repo/grantAgreement/EUR/SUDOE/INTERREG/Redvalue-SOE1-PI-E0123 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 7.0 2022 BIOCHEMISTRY & MOLECULAR BIOLOGY 46 / 285 = 0.161 2022 Q1 T1 FOOD SCIENCE & TECHNOLOGY 13 / 142 = 0.092 2022 Q1 T1 CHEMISTRY, MEDICINAL 6 / 60 = 0.1 2022 Q1 T1 1.084 2022 Biochemistry 2022 Q1 Clinical Biochemistry 2022 Q1 Food Science 2022 Q1 Physiology 2022 Q1 Molecular Biology 2022 Q2 Cell Biology 2022 Q2 8.8 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Ancín-Azpilicueta, Carmen Velderrain-Rodríguez, Gustavo Martin-Belloso, Olga Gualillo, Oreste Osada, Jesús Universidad de Zaragoza (orcid)0000-0002-8251-8457 Rodríguez-Yoldi, Maria Jesús Universidad de Zaragoza (orcid)0000-0002-3595-7668 Mendoza, Gracia (orcid)0000-0003-2293-363X 1012 410 Universidad de Zaragoza Dpto. Farmac.Fisiol.y Med.L.F. Área Fisiología 5005 555 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Ingeniería Química 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 11, 12 (2022), 2381 [14 pp.] Antioxidants Antioxidants 2076-3921 1440359 http://zaguan.unizar.es/record/120157/files/texto_completo.pdf Versión publicada 2694310 http://zaguan.unizar.es/record/120157/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:120157 articulos driver 2024-03-18-14:38:31 ARTICLE