000120188 001__ 120188
000120188 005__ 20240319081016.0
000120188 0247_ $$2doi$$a10.3390/v14112470
000120188 0248_ $$2sideral$$a131151
000120188 037__ $$aART-2022-131151
000120188 041__ $$aeng
000120188 100__ $$aLacote, Sandra
000120188 245__ $$aIntranasal Exposure to Rift Valley Fever Virus Live-Attenuated Strains Leads to High Mortality Rate in Immunocompetent Mice
000120188 260__ $$c2022
000120188 5060_ $$aAccess copy available to the general public$$fUnrestricted
000120188 5203_ $$aRift Valley fever virus (RVFV) is a pathogenic arthropod-borne virus that can cause serious illness in both ruminants and humans. The virus can be transmitted by an arthropod bite or contact with contaminated fluids or tissues. Two live-attenuated veterinary vaccines—the Smithburn (SB) and Clone 13 (Cl.13)—are currently used during epizootic events in Africa. However, their residual pathogenicity (i.e., SB) or potential of reversion (i.e., Cl.13) causes important adverse effects, strongly limiting their use in the field. In this study, we infected immunocompetent mice with SB or Cl.13 by a subcutaneous or an intranasal inoculation. Interestingly, we found that, unlike the subcutaneous infection, the intranasal inoculation led to a high mortality rate. In addition, we detected high titers and viral N antigen levels in the brain of both the SB- and Cl.13-infected mice. Overall, we unveil a clear correlation between the pathogenicity and the route of administration of both SB and Cl.13, with the intranasal inoculation leading to a stronger neurovirulence and higher mortality rate than the subcutaneous infection.
000120188 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000120188 590__ $$a4.7$$b2022
000120188 592__ $$a1.29$$b2022
000120188 591__ $$aVIROLOGY$$b15 / 36 = 0.417$$c2022$$dQ2$$eT2
000120188 593__ $$aInfectious Diseases$$c2022$$dQ1
000120188 593__ $$aVirology$$c2022$$dQ2
000120188 594__ $$a7.1$$b2022
000120188 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000120188 700__ $$aTamietti, Carole
000120188 700__ $$aChabert, Mehdi
000120188 700__ $$aConfort, Marie-Pierre
000120188 700__ $$aConquet, Laurine
000120188 700__ $$aPulido, Coralie
000120188 700__ $$aAurine, Noémie
000120188 700__ $$aBaquerre, Camille
000120188 700__ $$aThiesson, Adrien
000120188 700__ $$aPain, Bertrand
000120188 700__ $$0(orcid)0000-0003-3792-287X$$aDe Las Heras, Marcelo$$uUniversidad de Zaragoza
000120188 700__ $$aFlamand, Marie
000120188 700__ $$aMontagutelli, Xavier
000120188 700__ $$aMarianneau, Philippe
000120188 700__ $$aRatinier, Maxime
000120188 700__ $$aArnaud, Frédérick
000120188 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000120188 773__ $$g14, 11 (2022), 2470 [14 pp.]$$pVIRUSES-BASEL$$tVIRUSES-BASEL$$x1999-4915
000120188 8564_ $$s1552872$$uhttps://zaguan.unizar.es/record/120188/files/texto_completo.pdf$$yVersión publicada
000120188 8564_ $$s2829077$$uhttps://zaguan.unizar.es/record/120188/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000120188 909CO $$ooai:zaguan.unizar.es:120188$$particulos$$pdriver
000120188 951__ $$a2024-03-18-15:40:33
000120188 980__ $$aARTICLE