000120197 001__ 120197
000120197 005__ 20241125101126.0
000120197 0247_ $$2doi$$a10.1007/s00431-022-04702-6
000120197 0248_ $$2sideral$$a131222
000120197 037__ $$aART-2023-131222
000120197 041__ $$aeng
000120197 100__ $$aGonzález-Gil, Esther M.
000120197 245__ $$aLongitudinal associations between cardiovascular biomarkers and metabolic syndrome during puberty: the PUBMEP study
000120197 260__ $$c2023
000120197 5060_ $$aAccess copy available to the general public$$fUnrestricted
000120197 5203_ $$aPuberty has been described as a life stage of considerable metabolic risk specially for those with obesity. The low-grade systemic inflammatory status associated with obesity could be one of the connections with metabolic syndrome (MetS). Thus, we aimed to assess the relationship between inflammatory and cardiovascular biomarkers and the development of MetS during puberty. Seventy-five children from the PUBMEP study (33 females), aged 4–18 years, were included. Cardiovascular and inflammatory biomarkers were measured in the prepubertal and pubertal stage, including high-sensitivity C-reactive protein (CRP), leptin, tumor necrosis factor-alpha (TNFα), interleukin 8 (IL8), monocyte chemoattractant protein 1 (MCP-1), total plasminogen activator inhibitor-1 (tPAI), resistin, adiponectin, myeloperoxidase (MPO), and soluble intercellular adhesion molecule-1 (sICAM-1). MetS was diagnosed at each measurement point. Mixed-effects and logistic regressions were performed. Those children with MetS in puberty presented higher prepubertal values of several cardiometabolic biomarkers in comparison to those without MetS (z-score body mass index (zBMI), waist circumference, insulin, HOMA-IR, leptin, and tPAI (p < 0.05)). For prepubertal children with obesity, the odds of developing MetS in puberty were significantly higher in those having high zBMI (OR = 4.27; CI: 1.39–22.59) or high concentrations of tPAI (OR = 1.19; CI: 1.06–1.43)
000120197 536__ $$9info:eu-repo/grantAgreement/ES/CIBERObn/CB15-00043$$9info:eu-repo/grantAgreement/ES/CIBERObn/CB15-00131$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI11-01425$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI11-02042$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI11-02059$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI16-00871$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI16-01205$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI16-01301$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI20-00563
000120197 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000120197 590__ $$a3.0$$b2023
000120197 592__ $$a0.984$$b2023
000120197 591__ $$aPEDIATRICS$$b26 / 186 = 0.14$$c2023$$dQ1$$eT1
000120197 593__ $$aPediatrics, Perinatology and Child Health$$c2023$$dQ1
000120197 594__ $$a5.9$$b2023
000120197 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000120197 700__ $$aAnguita-Ruiz, Augusto
000120197 700__ $$aKalén, Anton
000120197 700__ $$aDe las Lamas Perez, Carmela
000120197 700__ $$0(orcid)0000-0002-3850-8235$$aRupérez, Azahara I.
000120197 700__ $$aVázquez-Cobela, Rocio
000120197 700__ $$aFlores, Katherine
000120197 700__ $$aGil, Angel
000120197 700__ $$aGil-Campos, Mercedes
000120197 700__ $$0(orcid)0000-0002-0902-387X$$aBueno, Gloria$$uUniversidad de Zaragoza
000120197 700__ $$aLeis, Rosaura
000120197 700__ $$aAguilera, Concepción M.
000120197 7102_ $$11011$$2670$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Pediatría
000120197 773__ $$g182, 1 (2023), 419–429$$pEur. j. pediatr.$$tEuropean Journal of Pediatrics$$x0340-6199
000120197 8564_ $$s781971$$uhttps://zaguan.unizar.es/record/120197/files/texto_completo.pdf$$yVersión publicada
000120197 8564_ $$s2228629$$uhttps://zaguan.unizar.es/record/120197/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000120197 909CO $$ooai:zaguan.unizar.es:120197$$particulos$$pdriver
000120197 951__ $$a2024-11-22-11:57:48
000120197 980__ $$aARTICLE