120197 20241125101126.0 doi 10.1007/s00431-022-04702-6 sideral 131222 ART-2023-131222 eng González-Gil, Esther M. Longitudinal associations between cardiovascular biomarkers and metabolic syndrome during puberty: the PUBMEP study 2023 Access copy available to the general public Unrestricted Puberty has been described as a life stage of considerable metabolic risk specially for those with obesity. The low-grade systemic inflammatory status associated with obesity could be one of the connections with metabolic syndrome (MetS). Thus, we aimed to assess the relationship between inflammatory and cardiovascular biomarkers and the development of MetS during puberty. Seventy-five children from the PUBMEP study (33 females), aged 4–18 years, were included. Cardiovascular and inflammatory biomarkers were measured in the prepubertal and pubertal stage, including high-sensitivity C-reactive protein (CRP), leptin, tumor necrosis factor-alpha (TNFα), interleukin 8 (IL8), monocyte chemoattractant protein 1 (MCP-1), total plasminogen activator inhibitor-1 (tPAI), resistin, adiponectin, myeloperoxidase (MPO), and soluble intercellular adhesion molecule-1 (sICAM-1). MetS was diagnosed at each measurement point. Mixed-effects and logistic regressions were performed. Those children with MetS in puberty presented higher prepubertal values of several cardiometabolic biomarkers in comparison to those without MetS (z-score body mass index (zBMI), waist circumference, insulin, HOMA-IR, leptin, and tPAI (p < 0.05)). For prepubertal children with obesity, the odds of developing MetS in puberty were significantly higher in those having high zBMI (OR = 4.27; CI: 1.39–22.59) or high concentrations of tPAI (OR = 1.19; CI: 1.06–1.43) info:eu-repo/grantAgreement/ES/CIBERObn/CB15-00043 info:eu-repo/grantAgreement/ES/CIBERObn/CB15-00131 info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI11-01425 info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI11-02042 info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI11-02059 info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI16-00871 info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI16-01205 info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI16-01301 info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI20-00563 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 3.0 2023 PEDIATRICS 26 / 186 = 0.14 2023 Q1 T1 0.984 2023 Pediatrics, Perinatology and Child Health 2023 Q1 5.9 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Anguita-Ruiz, Augusto Kalén, Anton De las Lamas Perez, Carmela Rupérez, Azahara I. (orcid)0000-0002-3850-8235 Vázquez-Cobela, Rocio Flores, Katherine Gil, Angel Gil-Campos, Mercedes Bueno, Gloria Universidad de Zaragoza (orcid)0000-0002-0902-387X Leis, Rosaura Aguilera, Concepción M. 1011 670 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Pediatría 182, 1 (2023), 419–429 Eur. j. pediatr. European Journal of Pediatrics 0340-6199 781971 http://zaguan.unizar.es/record/120197/files/texto_completo.pdf Versión publicada 2228629 http://zaguan.unizar.es/record/120197/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:120197 articulos driver 2024-11-22-11:57:48 ARTICLE