000120199 001__ 120199
000120199 005__ 20240319081016.0
000120199 0247_ $$2doi$$a10.3390/ijms232112947
000120199 0248_ $$2sideral$$a131155
000120199 037__ $$aART-2022-131155
000120199 041__ $$aeng
000120199 100__ $$aCiveira Marín, María
000120199 245__ $$aAPOE genotypes modulate inflammation independently of their effect on lipid metabolism
000120199 260__ $$c2022
000120199 5060_ $$aAccess copy available to the general public$$fUnrestricted
000120199 5203_ $$aThe association between APOE genotypes and cardiovascular disease (CVD) is partially mediated by LDL-cholesterol concentration but persists after adjusting for lipid levels and other cardiovascular risk factors. Data from the Aragon Workers Health Study (AWHS) (n = 4159) and the Lipid Unit at the Hospital Universitario Miguel Servet (HUMS) (n = 3705) were used to investigate the relationship between C-reactive protein (CRP) levels and APOE genotype. Lipoprotein particle and GlycA concentrations were analyzed in a subsample from AWHS. APOE genotyping was carried out by the Sanger method in both cohorts. APOE4 carriers had significantly lower levels of CRP than APOE3 carriers. Furthermore, APOE4 carriers had cholesterol-enriched LDL particles compared to APOE2 carriers. APOE4 carriers also had higher concentrations of small, medium, and large LDL particles. CRP levels were not associated with lipoprotein particle number, size, or composition. GlycA levels were not associated with APOE genotypes. However, GlycA levels were significantly associated with the size and the amount of cholesterol contained in HDL, VLDL, and LDL particles. APOE genotype influences CRP concentration regardless of lipid profile. APOE2 carriers showed the highest CRP levels, followed by APOE3 and APOE4. A more atherogenic lipid profile, but not inflammatory markers could partly explain the higher CVD risk observed in APOE4 carriers.
000120199 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B14-7R$$9info:eu-repo/grantAgreement/ES/ISCIII-MINECO/PI19-00694$$9info:eu-repo/grantAgreement/ES/MICINN-ISCIII/PI18-01777
000120199 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000120199 590__ $$a5.6$$b2022
000120199 592__ $$a1.154$$b2022
000120199 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b66 / 285 = 0.232$$c2022$$dQ1$$eT1
000120199 593__ $$aMedicine (miscellaneous)$$c2022$$dQ1
000120199 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b52 / 178 = 0.292$$c2022$$dQ2$$eT1
000120199 593__ $$aPhysical and Theoretical Chemistry$$c2022$$dQ1
000120199 593__ $$aComputer Science Applications$$c2022$$dQ1
000120199 593__ $$aInorganic Chemistry$$c2022$$dQ1
000120199 593__ $$aSpectroscopy$$c2022$$dQ1
000120199 593__ $$aOrganic Chemistry$$c2022$$dQ1
000120199 593__ $$aMolecular Biology$$c2022$$dQ2
000120199 593__ $$aCatalysis$$c2022$$dQ2
000120199 594__ $$a7.8$$b2022
000120199 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000120199 700__ $$aCenarro, Ana
000120199 700__ $$aMarco-Benedí, Victoria$$uUniversidad de Zaragoza
000120199 700__ $$aBea, Ana M.
000120199 700__ $$0(orcid)0000-0001-6650-8294$$aMateo-Gallego, Rocío$$uUniversidad de Zaragoza
000120199 700__ $$0(orcid)0000-0003-0604-5042$$aMoreno-Franco, Belén$$uUniversidad de Zaragoza
000120199 700__ $$aOrdovás, José M.
000120199 700__ $$0(orcid)0000-0003-3963-0846$$aLaclaustra, Martín$$uUniversidad de Zaragoza
000120199 700__ $$0(orcid)0000-0001-7043-0952$$aCiveira, Fernando$$uUniversidad de Zaragoza
000120199 700__ $$0(orcid)0000-0002-9647-0108$$aLamiquiz-Moneo, Itziar$$uUniversidad de Zaragoza
000120199 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000120199 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000120199 7102_ $$11003$$2027$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Anatom.Embriol.Humana
000120199 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ.
000120199 773__ $$g23, 21 (2022), 12947 [11 pp.]$$pInt. j. mol. sci.$$tInternational Journal of Molecular Sciences$$x1661-6596
000120199 8564_ $$s727146$$uhttps://zaguan.unizar.es/record/120199/files/texto_completo.pdf$$yVersión publicada
000120199 8564_ $$s2691595$$uhttps://zaguan.unizar.es/record/120199/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000120199 909CO $$ooai:zaguan.unizar.es:120199$$particulos$$pdriver
000120199 951__ $$a2024-03-18-15:41:58
000120199 980__ $$aARTICLE