120199 20240319081016.0 doi 10.3390/ijms232112947 sideral 131155 ART-2022-131155 eng Civeira Marín, María APOE genotypes modulate inflammation independently of their effect on lipid metabolism 2022 Access copy available to the general public Unrestricted The association between APOE genotypes and cardiovascular disease (CVD) is partially mediated by LDL-cholesterol concentration but persists after adjusting for lipid levels and other cardiovascular risk factors. Data from the Aragon Workers Health Study (AWHS) (n = 4159) and the Lipid Unit at the Hospital Universitario Miguel Servet (HUMS) (n = 3705) were used to investigate the relationship between C-reactive protein (CRP) levels and APOE genotype. Lipoprotein particle and GlycA concentrations were analyzed in a subsample from AWHS. APOE genotyping was carried out by the Sanger method in both cohorts. APOE4 carriers had significantly lower levels of CRP than APOE3 carriers. Furthermore, APOE4 carriers had cholesterol-enriched LDL particles compared to APOE2 carriers. APOE4 carriers also had higher concentrations of small, medium, and large LDL particles. CRP levels were not associated with lipoprotein particle number, size, or composition. GlycA levels were not associated with APOE genotypes. However, GlycA levels were significantly associated with the size and the amount of cholesterol contained in HDL, VLDL, and LDL particles. APOE genotype influences CRP concentration regardless of lipid profile. APOE2 carriers showed the highest CRP levels, followed by APOE3 and APOE4. A more atherogenic lipid profile, but not inflammatory markers could partly explain the higher CVD risk observed in APOE4 carriers. info:eu-repo/grantAgreement/ES/DGA/B14-7R info:eu-repo/grantAgreement/ES/ISCIII-MINECO/PI19-00694 info:eu-repo/grantAgreement/ES/MICINN-ISCIII/PI18-01777 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 5.6 2022 BIOCHEMISTRY & MOLECULAR BIOLOGY 66 / 285 = 0.232 2022 Q1 T1 CHEMISTRY, MULTIDISCIPLINARY 52 / 178 = 0.292 2022 Q2 T1 1.154 2022 Medicine (miscellaneous) 2022 Q1 Physical and Theoretical Chemistry 2022 Q1 Computer Science Applications 2022 Q1 Inorganic Chemistry 2022 Q1 Spectroscopy 2022 Q1 Organic Chemistry 2022 Q1 Molecular Biology 2022 Q2 Catalysis 2022 Q2 7.8 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Cenarro, Ana Marco-Benedí, Victoria Universidad de Zaragoza Bea, Ana M. Mateo-Gallego, Rocío Universidad de Zaragoza (orcid)0000-0001-6650-8294 Moreno-Franco, Belén Universidad de Zaragoza (orcid)0000-0003-0604-5042 Ordovás, José M. Laclaustra, Martín Universidad de Zaragoza (orcid)0000-0003-3963-0846 Civeira, Fernando Universidad de Zaragoza (orcid)0000-0001-7043-0952 Lamiquiz-Moneo, Itziar Universidad de Zaragoza (orcid)0000-0002-9647-0108 1006 255 Universidad de Zaragoza Dpto. Fisiatría y Enfermería Área Enfermería 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 1003 027 Universidad de Zaragoza Dpto. Anatom.Histolog.Humanas Area Anatom.Embriol.Humana 1011 615 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Medic.Prevent.Salud Públ. 23, 21 (2022), 12947 [11 pp.] Int. j. mol. sci. International Journal of Molecular Sciences 1661-6596 727146 http://zaguan.unizar.es/record/120199/files/texto_completo.pdf Versión publicada 2691595 http://zaguan.unizar.es/record/120199/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:120199 articulos driver 2024-03-18-15:41:58 ARTICLE