000120247 001__ 120247 000120247 005__ 20240319081026.0 000120247 0247_ $$2doi$$a10.3390/jpm12060894 000120247 0248_ $$2sideral$$a131216 000120247 037__ $$aART-2022-131216 000120247 041__ $$aeng 000120247 100__ $$aGarcía-Mesa, Yolanda 000120247 245__ $$aMerkel Cell Carcinoma Display PIEZO2 Immunoreactivity 000120247 260__ $$c2022 000120247 5060_ $$aAccess copy available to the general public$$fUnrestricted 000120247 5203_ $$aAs an essential component of mechano-gated ion channels, critically required for mechanotransduction in mammalian cells, PIEZO2 is known to be characteristically expressed by Merkel cells in human skin. Here, we immunohistochemically investigated the occurrence of Piezo channels in a case series of Merkel cell carcinoma. A panel of antibodies was used to characterize Merkel cells, and to detect PIEZO2 expression. All analyzed tumors displayed PIEZO2 in nearly all cells, showing two patterns of immunostaining: membranous and perinuclear dot-like. PIEZO2 co-localized with cytokeratin 20, chromogranin A, synaptophysin and neurofilament. Moreover, neurofilament immunoreactive structures resembling nerve-Merkel cell contacts were occasionally found. PIEZO2 was also detected in cells of the sweat ducts. The role of PIEZO2 in Merkel cell carcinoma is still unknown, but it could be related with the mechanical regulation of the tumor biology or be a mere vestige of the Merkel cell derivation. 000120247 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000120247 590__ $$a3.4$$b2022 000120247 592__ $$a0.665$$b2022 000120247 591__ $$aMEDICINE, GENERAL & INTERNAL$$b67 / 169 = 0.396$$c2022$$dQ2$$eT2 000120247 593__ $$aMedicine (miscellaneous)$$c2022$$dQ2 000120247 591__ $$aHEALTH CARE SCIENCES & SERVICES$$b42 / 106 = 0.396$$c2022$$dQ2$$eT2 000120247 594__ $$a2.6$$b2022 000120247 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000120247 700__ $$aMartín-Sanz, Raquel 000120247 700__ $$0(orcid)0000-0002-2501-6653$$aGarcía-Piqueras, Jorge 000120247 700__ $$aCobo, Ramón 000120247 700__ $$aMuñoz-Bravo, Saray 000120247 700__ $$aGarcía-Suárez, Olivia 000120247 700__ $$aMartín-Biedma, Benjamín 000120247 700__ $$aVega, José Antonio 000120247 700__ $$aFeito, Jorge 000120247 773__ $$g12, 6 (2022), 894 [8 pp.]$$pJ. pers. med.$$tJournal of Personalized Medicine$$x2075-4426 000120247 8564_ $$s8923254$$uhttps://zaguan.unizar.es/record/120247/files/texto_completo.pdf$$yVersión publicada 000120247 8564_ $$s2823784$$uhttps://zaguan.unizar.es/record/120247/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000120247 909CO $$ooai:zaguan.unizar.es:120247$$particulos$$pdriver 000120247 951__ $$a2024-03-18-16:43:58 000120247 980__ $$aARTICLE