120247 20240319081026.0 doi 10.3390/jpm12060894 sideral 131216 ART-2022-131216 eng García-Mesa, Yolanda Merkel Cell Carcinoma Display PIEZO2 Immunoreactivity 2022 Access copy available to the general public Unrestricted As an essential component of mechano-gated ion channels, critically required for mechanotransduction in mammalian cells, PIEZO2 is known to be characteristically expressed by Merkel cells in human skin. Here, we immunohistochemically investigated the occurrence of Piezo channels in a case series of Merkel cell carcinoma. A panel of antibodies was used to characterize Merkel cells, and to detect PIEZO2 expression. All analyzed tumors displayed PIEZO2 in nearly all cells, showing two patterns of immunostaining: membranous and perinuclear dot-like. PIEZO2 co-localized with cytokeratin 20, chromogranin A, synaptophysin and neurofilament. Moreover, neurofilament immunoreactive structures resembling nerve-Merkel cell contacts were occasionally found. PIEZO2 was also detected in cells of the sweat ducts. The role of PIEZO2 in Merkel cell carcinoma is still unknown, but it could be related with the mechanical regulation of the tumor biology or be a mere vestige of the Merkel cell derivation. info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 3.4 2022 MEDICINE, GENERAL & INTERNAL 67 / 169 = 0.396 2022 Q2 T2 HEALTH CARE SCIENCES & SERVICES 42 / 106 = 0.396 2022 Q2 T2 0.665 2022 Medicine (miscellaneous) 2022 Q2 2.6 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Martín-Sanz, Raquel García-Piqueras, Jorge (orcid)0000-0002-2501-6653 Cobo, Ramón Muñoz-Bravo, Saray García-Suárez, Olivia Martín-Biedma, Benjamín Vega, José Antonio Feito, Jorge 12, 6 (2022), 894 [8 pp.] J. pers. med. Journal of Personalized Medicine 2075-4426 8923254 http://zaguan.unizar.es/record/120247/files/texto_completo.pdf Versión publicada 2823784 http://zaguan.unizar.es/record/120247/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:120247 articulos driver 2024-03-18-16:43:58 ARTICLE