120913 20240319081003.0 doi 10.3389/fbioe.2022.981665 sideral 131245 ART-2022-131245 eng Redaelli, Elena Universidad de Zaragoza A detailed methodology to model the Non Contact Tonometry: a Fluid Structure Interaction study 2022 Access copy available to the general public Unrestricted Understanding the corneal mechanical properties has great importance in the study of corneal pathologies and the prediction of refractive surgery outcomes. Non-Contact Tonometry (NCT) is a non-invasive diagnostic tool intended to characterize the corneal tissue response in vivo by applying a defined air-pulse. The biomarkers inferred from this test can only be considered as indicators of the global biomechanical behaviour rather than the intrinsic biomechanical properties of the corneal tissue. A possibility to isolate the mechanical response of the corneal tissue is the use of an inverse finite element method, which is based on accurate and reliable modelling. Since a detailed methodology is still missing in the literature, this paper aims to construct a high-fidelity finite-element model of an idealized 3D eye for in silico NCT. A fluid-structure interaction (FSI) simulation is developed to virtually apply a defined air-pulse to a 3D idealized eye model comprising cornea, limbus, sclera, lens and humors. Then, a sensitivity analysis is performed to examine the influence of the intraocular pressure (IOP) and the structural material parameters on three biomarkers associated with corneal deformation. The analysis reveals the requirements for the in silico study linked to the correct reproduction of three main aspects: the air pressure over the cornea, the biomechanical properties of the tissues, and the IOP. The adoption of an FSI simulation is crucial to capture the correct air pressure profile over the cornea as a consequence of the air-jet. Regarding the parts of the eye, an anisotropic material should be used for the cornea. An important component is the sclera: the stiffer the sclera, the lower the corneal deformation due to the air-puff. Finally, the fluid-like behavior of the humors should be considered in order to account for the correct variation of the IOP during the test which will, otherwise, remain constant. The development of a strong FSI tool amenable to model coupled structures and fluids provides the basis to find the biomechanical properties of the corneal tissue in vivo. info:eu-repo/grantAgreement/ES/DGA-FSE/T24-20R info:eu-repo/grantAgreement/EC/H2020/956720/EU/Opto-Biomechanical Eye Research Network/OBERON This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 956720-OBERON info:eu-repo/grantAgreement/ES/MICINN/PID2020-113822RB-C21 info:eu-repo/grantAgreement/ES/UZ/ICTS NANBIOSIS-U27 Unit-CIBER-BBN info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 5.7 2022 MULTIDISCIPLINARY SCIENCES 16 / 73 = 0.219 2022 Q1 T1 0.93 2022 Biomedical Engineering 2022 Q1 Biotechnology 2022 Q1 Histology 2022 Q2 Bioengineering 2022 Q2 6.7 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Grasa, Jorge Universidad de Zaragoza (orcid)0000-0002-6870-0594 Calvo, Begoña Universidad de Zaragoza (orcid)0000-0001-9713-1813 Rodriguez Matas, Jose Felix (orcid)0000-0001-7612-266X Luraghi, Giulia 5004 605 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Mec.Med.Cont. y Teor.Est. 10 (2022), 981665 [12 pp.] Front. Bioeng. Biotechnol. Frontiers in Bioengineering and Biotechnology 2296-4185 1857473 http://zaguan.unizar.es/record/120913/files/texto_completo.pdf Versión publicada 2091355 http://zaguan.unizar.es/record/120913/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:120913 articulos driver 2024-03-18-14:22:23 ARTICLE