000120916 001__ 120916
000120916 005__ 20240319081003.0
000120916 0247_ $$2doi$$a10.1016/j.arr.2022.101778
000120916 0248_ $$2sideral$$a131280
000120916 037__ $$aART-2022-131280
000120916 041__ $$aeng
000120916 100__ $$0(orcid)0000-0002-7865-3429$$aLópez-Bueno, Rubén
000120916 245__ $$aThresholds of handgrip strength for all-cause, cancer, and cardiovascular mortality: A systematic review with dose-response meta-analysis
000120916 260__ $$c2022
000120916 5060_ $$aAccess copy available to the general public$$fUnrestricted
000120916 5203_ $$aBackground
While handgrip strength is associated with all-cause and cause-specific mortality, whether such associations are dose-dependent is largely unknown. Therefore, we conducted a systematic review on the dose-response relationship of handgrip strength with all-cause mortality, cancer, and cardiovascular mortality.
Methods
The data source included three electronic databases (PubMed/MEDLINE, Web of Science and Scopus) from inception to 8 February 2022. Prospective cohort studies of healthy adults with objective measures of handgrip strength were included. Two researchers independently screened studies, extracted data, and assessed risk of bias. We used estimates regarding handgrip strength categories to conduct a random forest model, and a two-stage random-effects hierarchical meta-regression model pooling study-specific estimates for dose-response relationship. Outcomes included all-cause, cancer, and cardiovascular mortality.
Reults
Forty-eight studies comprising 3,135,473 participants (49.6% women, age range 35–85 years) were included. Random forest models showed a significant inverse association between handgrip strength and all-cause and cause-specific mortality. Dose-response meta-analyses showed that higher levels of handgrip strength significantly reduced the risk of all-cause mortality within 26–50 kg (Higgin´s I2 =45.7%) in a close-to-linear inverse fashion. Cancer and cardiovascular mortality displayed a trend towards a U-shaped association with a significant risk reduction between 16 and 33 kg (Higgin´s I2 =77.4%), and a close-to-linear inverse shaped and significant risk reduction ranging from 24 to 40 kg (Higgin´s I2 =79.7%) respectively.
Conclusion
There is strong evidence for an association between lower handgrip strength with higher all-cause, cancer, and cardiovascular mortality risk. The dose-response relationship of handgrip strength substantially varies depending on the cause of mortality.
000120916 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000120916 590__ $$a13.1$$b2022
000120916 592__ $$a3.007$$b2022
000120916 591__ $$aGERIATRICS & GERONTOLOGY$$b1 / 54 = 0.019$$c2022$$dQ1$$eT1
000120916 593__ $$aAging$$c2022$$dQ1
000120916 591__ $$aCELL BIOLOGY$$b20 / 191 = 0.105$$c2022$$dQ1$$eT1
000120916 593__ $$aBiochemistry$$c2022$$dQ1
000120916 593__ $$aNeurology$$c2022$$dQ1
000120916 593__ $$aMolecular Biology$$c2022$$dQ1
000120916 593__ $$aBiotechnology$$c2022$$dQ1
000120916 594__ $$a17.5$$b2022
000120916 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000120916 700__ $$aAndersen, Lars Louis
000120916 700__ $$aKoyanagi, Ai
000120916 700__ $$aNúñez-Cortés, Rodrigo
000120916 700__ $$aCalatayud, Joaquín
000120916 700__ $$aCasaña, José
000120916 700__ $$adel Pozo Cruz, Borja
000120916 773__ $$g82 (2022), 101778 [12 pp.]$$pAGEING RES REV$$tAgeing Research Reviews$$x1568-1637
000120916 8564_ $$s3634035$$uhttps://zaguan.unizar.es/record/120916/files/texto_completo.pdf$$yVersión publicada
000120916 8564_ $$s2392302$$uhttps://zaguan.unizar.es/record/120916/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000120916 909CO $$ooai:zaguan.unizar.es:120916$$particulos$$pdriver
000120916 951__ $$a2024-03-18-14:22:34
000120916 980__ $$aARTICLE