000120927 001__ 120927
000120927 005__ 20240319081005.0
000120927 0247_ $$2doi$$a10.1021/acsami.2c17558
000120927 0248_ $$2sideral$$a131276
000120927 037__ $$aART-2022-131276
000120927 041__ $$aeng
000120927 100__ $$aHuang, Zhiwei
000120927 245__ $$aTwo-dimensional Triblock Peptide assemblies for the stabilization of Pickering emulsions with pH responsiveness
000120927 260__ $$c2022
000120927 5060_ $$aAccess copy available to the general public$$fUnrestricted
000120927 5203_ $$aA variety of two-dimensional (2D) nanomaterials, including graphene oxide and clays, are known to stabilize Pickering emulsions to fabricate structures for functions in sensors, catalysts, and encapsulation. We introduce here a novel Pickering emulsion using self-assembled amphiphilic triblock oligoglycine as the emulsifier. Peptide amphiphiles are more responsive to environmental changes (e.g., pH, temperature, and ionic strength) than inorganic 2D materials, which have a chemically rigid, in-plane structure. Noncovalent forces between the peptide molecules change with the environment, thereby imparting responsiveness. We provide new evidence that the biantennary oligoglycine, Gly4–NH–C10H20–NH–Gly4, self-assembles into 2D platelet structures, denoted as tectomers, in solution at a neutral buffered pH using small-angle X-ray scattering and molecular dynamics simulations. The molecules are stacked in the platelets with a linear conformation, rather than in a U-shape. We discovered that the lamellar oligoglycine platelets adsorbed at an oil/water interface and stabilized oil-in-water emulsions. This is the first report of 2D oligoglycine platelets being used as a Pickering stabilizer. The emulsions showed a strong pH response in an acidic environment. Thus, upon reducing the pH, the protonation of the terminal amino groups of the oligoglycine induced disassembly of the lamellar structure due to repulsive electrostatic forces, leading to emulsion destabilization. To demonstrate the application of the material, we show that a model active ingredient, β-carotene, in the oil is released upon decreasing the pH. Interestingly, in pH 9 buffer, the morphology of the oil droplets evolved over time, as the oligoglycine stabilizer created progressively a thicker interfacial layer. This demonstration opens a new route to use self-assembled synthetic peptide amphiphiles to stabilize Pickering emulsions, which can be significant for biomedical and pharmaceutical applications.
000120927 536__ $$9info:eu-repo/grantAgreement/ES/DGA/E25-20R
000120927 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000120927 590__ $$a9.5$$b2022
000120927 592__ $$a2.178$$b2022
000120927 591__ $$aNANOSCIENCE & NANOTECHNOLOGY$$b27 / 107 = 0.252$$c2022$$dQ2$$eT1
000120927 593__ $$aMaterials Science (miscellaneous)$$c2022$$dQ1
000120927 591__ $$aMATERIALS SCIENCE, MULTIDISCIPLINARY$$b55 / 343 = 0.16$$c2022$$dQ1$$eT1
000120927 593__ $$aNanoscience and Nanotechnology$$c2022$$dQ1
000120927 593__ $$aMedicine (miscellaneous)$$c2022$$dQ1
000120927 594__ $$a15.7$$b2022
000120927 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000120927 700__ $$aCalicchia, Eleonora
000120927 700__ $$aJurewicz, Izabela
000120927 700__ $$aMuñoz, Edgar
000120927 700__ $$0(orcid)0000-0003-2607-7834$$aGarriga, Rosa$$uUniversidad de Zaragoza
000120927 700__ $$aPortale, Giuseppe
000120927 700__ $$aHowlin, Brendan J.
000120927 700__ $$aKeddie, Joseph L.
000120927 7102_ $$12012$$2755$$aUniversidad de Zaragoza$$bDpto. Química Física$$cÁrea Química Física
000120927 773__ $$g14, 47 (2022), 53228-53240$$pACS appl. mater. interfaces$$tACS applied materials & interfaces$$x1944-8244
000120927 8564_ $$s11208704$$uhttps://zaguan.unizar.es/record/120927/files/texto_completo.pdf$$yVersión publicada
000120927 8564_ $$s3360258$$uhttps://zaguan.unizar.es/record/120927/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000120927 909CO $$ooai:zaguan.unizar.es:120927$$particulos$$pdriver
000120927 951__ $$a2024-03-18-14:34:22
000120927 980__ $$aARTICLE