120952 20240319081013.0 doi 10.3390/ijms232012609 sideral 131239 ART-2022-131239 eng Hernaiz, Adelaida Universidad de Zaragoza (orcid)0000-0002-6806-9990 Epigenetic Changes in Prion and Prion-like Neurodegenerative Diseases: Recent Advances, Potential as Biomarkers, and Future Perspectives 2022 Access copy available to the general public Unrestricted Prion diseases are transmissible spongiform encephalopathies (TSEs) caused by a conformational conversion of the native cellular prion protein (PrPC) to an abnormal, infectious isoform called PrPSc. Amyotrophic lateral sclerosis, Alzheimer’s, Parkinson’s, and Huntington’s diseases are also known as prion-like diseases because they share common features with prion diseases, including protein misfolding and aggregation, as well as the spread of these misfolded proteins into different brain regions. Increasing evidence proposes the involvement of epigenetic mechanisms, namely DNA methylation, post-translational modifications of histones, and microRNA-mediated post-transcriptional gene regulation in the pathogenesis of prion-like diseases. Little is known about the role of epigenetic modifications in prion diseases, but recent findings also point to a potential regulatory role of epigenetic mechanisms in the pathology of these diseases. This review highlights recent findings on epigenetic modifications in TSEs and prion-like diseases and discusses the potential role of such mechanisms in disease pathology and their use as potential biomarkers. info:eu-repo/grantAgreement/ES/DGA/A19-20R info:eu-repo/grantAgreement/ES/DGA-FEDER/Construyendo Europa desde Aragón info:eu-repo/grantAgreement/ES/DGA-FSE/IIU-2023-2017 info:eu-repo/grantAgreement/ES/MINECO/AGL2015-67945-P info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 5.6 2022 BIOCHEMISTRY & MOLECULAR BIOLOGY 66 / 285 = 0.232 2022 Q1 T1 CHEMISTRY, MULTIDISCIPLINARY 52 / 178 = 0.292 2022 Q2 T1 1.154 2022 Medicine (miscellaneous) 2022 Q1 Physical and Theoretical Chemistry 2022 Q1 Computer Science Applications 2022 Q1 Inorganic Chemistry 2022 Q1 Spectroscopy 2022 Q1 Organic Chemistry 2022 Q1 Molecular Biology 2022 Q2 Catalysis 2022 Q2 7.8 2022 info:eu-repo/semantics/review info:eu-repo/semantics/publishedVersion Toivonen, Janne Markus Universidad de Zaragoza (orcid)0000-0002-7243-1737 Bolea, Rosa Universidad de Zaragoza (orcid)0000-0002-2746-3932 Martín-Burriel, Inmaculada Universidad de Zaragoza (orcid)0000-0001-6016-4726 1001 420 Universidad de Zaragoza Dpto. Anatom.,Embri.Genét.Ani. Área Genética 1009 773 Universidad de Zaragoza Dpto. Patología Animal Área Sanidad Animal 23, 20 (2022), 12609 [28 pp.] Int. j. mol. sci. International Journal of Molecular Sciences 1661-6596 1027278 http://zaguan.unizar.es/record/120952/files/texto_completo.pdf Versión publicada 2790815 http://zaguan.unizar.es/record/120952/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:120952 articulos driver 2024-03-18-15:22:21 ARTICLE