000120953 001__ 120953
000120953 005__ 20240319081013.0
000120953 0247_ $$2doi$$a10.1021/acs.inorgchem.2c03015
000120953 0248_ $$2sideral$$a131244
000120953 037__ $$aART-2022-131244
000120953 041__ $$aeng
000120953 100__ $$aKomarnicka, Urszula K.
000120953 245__ $$aLiposomal Binuclear Ir(III)–Cu(II) Coordination Compounds with Phosphino-Fluoroquinolone Conjugates for Human Prostate Carcinoma Treatment
000120953 260__ $$c2022
000120953 5060_ $$aAccess copy available to the general public$$fUnrestricted
000120953 5203_ $$aNovel heteronuclear IrIII–CuII coordination compounds ([Ir(η5-Cp*)Cl2Pcfx-Cu(phen)](NO3)·1.75(CH3OH)·0.75(H2O) (1), [Ir(η5-Cp*)Cl2Pnfx-Cu(phen)](NO3)·1.75(CH3OH)·0.75(H2O) (2), [Ir(η5-Cp*)Cl2Plfx-Cu(phen)](NO3)·1.3(H2O)·1.95(CH3OH) (3), [Ir(η5-Cp*)Cl2Psfx-Cu(phen)] (4)) bearing phosphines derived from fluoroquinolones, namely, sparfloxacin (Hsfx), ciprofloxacin (Hcfx), lomefloxacin (Hlfx), and norfloxacin (Hnfx), have been synthesized and studied as possible anticancer chemotherapeutics. All compounds have been characterized by electrospray ionization mass spectrometry (ESI-MS), a number of spectroscopic methods (i.e., IR, fluorescence, and electron paramagnetic resonance (EPR)), cyclic voltammetry, variable-temperature magnetic susceptibility measurements, and X-ray diffractometry. The coordination geometry of IrIII in all complexes adopts a characteristic piano-stool geometry with the η5-coordinated and three additional sites occupied by two chloride and phosphine ligands, while CuII ions in complexes 1 and 2 form a distorted square-pyramidal coordination geometry, and in complex 3, the coordination geometry around CuII ions is a distorted octahedron. Interestingly, the crystal structure of [Ir(η5-Cp*)Cl2Plfx-Cu(phen)] features the one-dimensional (1D) metal–organic polymer. Liposomes loaded with redox-active and fluorescent [Ir(η5-Cp*)Cl2Pcfx-Cu(phen)] (1L) have been prepared to increase water solubility and minimize serious systemic side effects. It has been proven, by confocal microscopy and an inductively coupled plasma mass spectrometry (ICP-MS) analysis, that the liposomal form of compound 1 can be effectively accumulated inside human lung adenocarcinoma and human prostate carcinoma cells with selective localization in nuclei. A cytometric analysis showed dominance of apoptosis over the other cell death types. Furthermore, the investigated nanoformulations induced changes in the cell cycle, leading to S phase arrest in a dose-dependent manner. Importantly, in vitro anticancer action on three-dimensional (3D) multicellular tumor spheroids has been demonstrated.
000120953 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000120953 590__ $$a4.6$$b2022
000120953 592__ $$a0.997$$b2022
000120953 591__ $$aCHEMISTRY, INORGANIC & NUCLEAR$$b5 / 42 = 0.119$$c2022$$dQ1$$eT1
000120953 593__ $$aChemistry (miscellaneous)$$c2022$$dQ1
000120953 593__ $$aPhysical and Theoretical Chemistry$$c2022$$dQ1
000120953 593__ $$aInorganic Chemistry$$c2022$$dQ1
000120953 594__ $$a8.0$$b2022
000120953 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000120953 700__ $$aKoziel, Sandra
000120953 700__ $$aPucelik, Barbara
000120953 700__ $$aBarzowska, Agata
000120953 700__ $$aSiczek, Milosz
000120953 700__ $$aMalik, Magdalena
000120953 700__ $$aWojtala, Daria
000120953 700__ $$aNiorettini, Alessandro
000120953 700__ $$aKyziol, Agnieszka
000120953 700__ $$0(orcid)0000-0002-6873-5244$$aSebastian, Victor$$uUniversidad de Zaragoza
000120953 700__ $$aKopel, Pavel
000120953 700__ $$aCaramori, Stefano
000120953 700__ $$aBienko, Alina
000120953 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000120953 773__ $$g61, 48 (2022), 19261-19273$$pInorg. chem.$$tInorganic Chemistry$$x0020-1669
000120953 8564_ $$s9126524$$uhttps://zaguan.unizar.es/record/120953/files/texto_completo.pdf$$yVersión publicada
000120953 8564_ $$s3092654$$uhttps://zaguan.unizar.es/record/120953/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000120953 909CO $$ooai:zaguan.unizar.es:120953$$particulos$$pdriver
000120953 951__ $$a2024-03-18-15:22:27
000120953 980__ $$aARTICLE