000120955 001__ 120955
000120955 005__ 20240319081013.0
000120955 0247_ $$2doi$$a10.3390/microorganisms10050942
000120955 0248_ $$2sideral$$a131247
000120955 037__ $$aART-2022-131247
000120955 041__ $$aeng
000120955 100__ $$aMoreno, Edgardo
000120955 245__ $$aFacing the Human and Animal Brucellosis Conundrums: The Forgotten Lessons
000120955 260__ $$c2022
000120955 5060_ $$aAccess copy available to the general public$$fUnrestricted
000120955 5203_ $$aBrucellosis is a major zoonotic disease caused by Brucella species. Historically, the disease received over fifty names until it was recognized as a single entity, illustrating its protean manifestations and intricacies, traits that generated conundrums that have remained or re-emerged since they were first described. Here, we examine confusions concerning the clinical picture, serological diagnosis, and incidence of human brucellosis. We also discuss knowledge gaps and prevalent confusions about animal brucellosis, including brucellosis control strategies, the so-called confirmatory tests, and assumptions about the primary-binding assays and DNA detection methods. We describe how doubtfully characterized vaccines have failed to control brucellosis and emphasize how the requisites of controlled safety and protection experiments are generally overlooked. Finally, we briefly discuss the experience demonstrating that S19 remains the best cattle vaccine, while RB51 fails to validate its claimed properties (protection, differentiating infected and vaccinated animals (DIVA), and safety), offering a strong argument against its current widespread use. These conundrums show that knowledge dealing with brucellosis is lost, and previous experience is overlooked or misinterpreted, as illustrated in a significant number of misguided meta-analyses. In a global context of intensifying livestock breeding, such recurrent oversights threaten to increase the impact of brucellosis.
000120955 536__ $$9info:eu-repo/grantAgreement/ES/DGA/A13-17R$$9info:eu-repo/grantAgreement/ES/MINECO/PID2019-107601RA-C32
000120955 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000120955 590__ $$a4.5$$b2022
000120955 592__ $$a0.909$$b2022
000120955 591__ $$aMICROBIOLOGY$$b47 / 135 = 0.348$$c2022$$dQ2$$eT2
000120955 593__ $$aMicrobiology$$c2022$$dQ2
000120955 593__ $$aVirology$$c2022$$dQ2
000120955 593__ $$aMicrobiology (medical)$$c2022$$dQ2
000120955 594__ $$a6.4$$b2022
000120955 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000120955 700__ $$aBlasco, José-María
000120955 700__ $$aMoriyón, Ignacio
000120955 773__ $$g10, 5 (2022), 942 [29 pp.]$$pMicroorganisms$$tMicroorganisms$$x2076-2607
000120955 8564_ $$s2070908$$uhttps://zaguan.unizar.es/record/120955/files/texto_completo.pdf$$yVersión publicada
000120955 8564_ $$s2771542$$uhttps://zaguan.unizar.es/record/120955/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000120955 909CO $$ooai:zaguan.unizar.es:120955$$particulos$$pdriver
000120955 951__ $$a2024-03-18-15:22:35
000120955 980__ $$aARTICLE