000120965 001__ 120965
000120965 005__ 20241125101126.0
000120965 0247_ $$2doi$$a10.1177/03009858221137020
000120965 0248_ $$2sideral$$a131340
000120965 037__ $$aART-2023-131340
000120965 041__ $$aeng
000120965 100__ $$0(orcid)0000-0001-6629-6842$$aMoreno, B.$$uUniversidad de Zaragoza
000120965 245__ $$aPeripheral neuropathy caused by fenugreek (Trigonella foenum-graecum) straw intoxication in cattle and experimental reproduction in sheep and goats
000120965 260__ $$c2023
000120965 5060_ $$aAccess copy available to the general public$$fUnrestricted
000120965 5203_ $$aTrigonella foenum-graecum (fenugreek) is a legume widely used as a food supplement in humans and less frequently in ruminants. Toxicity has been described sporadically in ruminants grazing mature fenugreek plants or stubble; however, the pathological features are unclear. This report describes a natural outbreak of intoxication in cattle fed fenugreek straw and the experimental reproduction using 8 sheep and 8 goats. Affected cattle presented clinical signs approximately 1 month after consuming the straw and 100 of 400 cattle (25%) were affected, of which 60 of 100 (60%) died or were euthanized. Clinical signs were characterized by proprioceptive positioning defects with abnormal postures and weakness of hindlimbs. Forelimbs were also affected in severely affected animals, and cattle became recumbent. Locomotion was characterized by trembling, and some cattle showed high-stepping movements of their forelimbs and knuckled over in their fetlocks. Experimental intoxication induced clinical signs only in sheep and were similar to cattle, although with signs starting in the forelegs. Gross and microscopic lesions were similar in spontaneous and experimental intoxications. Macroscopic changes corresponded with muscular hemorrhages and edema, mainly surrounding the peripheral nerves. Microscopic examination only demonstrated lesions in the distal peripheral nerves, which included edema, hemorrhages, and Wallerian degeneration. Neurofilament immunohistochemistry revealed altered axon labeling and S100 showed a decrease in myelin intensity and loss of its typical compact arrangement around axons. Biochemical and hematological abnormalities included elevated levels of muscle and liver enzymes and thrombocytopenia. These findings indicate that fenugreek straw induces peripheral neuropathy in cattle and sheep, but not in goats.
000120965 536__ $$9info:eu-repo/grantAgreement/ES/DGA/A05-17R
000120965 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000120965 590__ $$a2.3$$b2023
000120965 592__ $$a0.749$$b2023
000120965 591__ $$aVETERINARY SCIENCES$$b28 / 167 = 0.168$$c2023$$dQ1$$eT1
000120965 593__ $$aVeterinary (miscellaneous)$$c2023$$dQ1
000120965 591__ $$aPATHOLOGY$$b42 / 88 = 0.477$$c2023$$dQ2$$eT2
000120965 594__ $$a4.7$$b2023
000120965 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000120965 700__ $$0(orcid)0000-0002-1590-3347$$aMarín, B.$$uUniversidad de Zaragoza
000120965 700__ $$0(orcid)0000-0001-9075-2764$$aOtero, A.$$uUniversidad de Zaragoza
000120965 700__ $$0(orcid)0000-0002-8752-5146$$aGarcía, M.$$uUniversidad de Zaragoza
000120965 700__ $$aRaksa, H.
000120965 700__ $$aGuijarro, M. I.
000120965 700__ $$0(orcid)0000-0002-0606-0763$$aCliment, M.$$uUniversidad de Zaragoza
000120965 700__ $$0(orcid)0000-0001-9778-6545$$aMorales, M.$$uUniversidad de Zaragoza
000120965 700__ $$aZabala, J.
000120965 700__ $$aLoste, J. M.
000120965 700__ $$0(orcid)0000-0001-5105-6133$$aAcín, C.$$uUniversidad de Zaragoza
000120965 700__ $$0(orcid)0000-0002-7173-7216$$aBadiola, J. J.$$uUniversidad de Zaragoza
000120965 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética
000120965 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000120965 7102_ $$11001$$2025$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Anatom.Anatom.Patológ.Com
000120965 773__ $$g60, 1 (2023), 115-122$$pVet. pathol.$$tVeterinary Pathology$$x0300-9858
000120965 8564_ $$s4216039$$uhttps://zaguan.unizar.es/record/120965/files/texto_completo.pdf$$yPostprint
000120965 8564_ $$s1691515$$uhttps://zaguan.unizar.es/record/120965/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000120965 909CO $$ooai:zaguan.unizar.es:120965$$particulos$$pdriver
000120965 951__ $$a2024-11-22-11:57:44
000120965 980__ $$aARTICLE