000120972 001__ 120972
000120972 005__ 20240319081015.0
000120972 0247_ $$2doi$$a10.1007/s10237-022-01627-9
000120972 0248_ $$2sideral$$a131483
000120972 037__ $$aART-2022-131483
000120972 041__ $$aeng
000120972 100__ $$0(orcid)0000-0003-4128-2836$$aRíos-Ruiz, Itziar$$uUniversidad de Zaragoza
000120972 245__ $$aIs location a significant parameter in the layer dependent dissection properties of the aorta?
000120972 260__ $$c2022
000120972 5060_ $$aAccess copy available to the general public$$fUnrestricted
000120972 5203_ $$aProper characterisation of biological tissue is key to understanding the effect of the biomechanical environment in the physiology and pathology of the cardiovascular system. Aortic dissection in particular is a prevalent and sometimes fatal disease that still lacks a complete comprehension of its progression. Its development and outcome, however, depend on the location in the vessel. Dissection properties of arteries are frequently studied via delamination tests, such as the T-peel test and the mixed-mode peel test. So far, a study that performs both tests throughout different locations of the aorta, as well as dissecting several interfaces, is missing. This makes it difficult to extract conclusions in terms of vessel heterogeneity, as a standardised experimental procedure cannot be assured for different studies in literature. Therefore, both dissection tests have been here performed on healthy porcine aortas, dissecting three interfaces of the vessels, i.e., the intima-media, the media-adventitia and the media within itself, considering different locations of the aorta, the ascending thoracic aorta (ATA), the descending thoracic aorta and the infrarenal abdominal aorta (IAA). Significant differences were found for both, layers and location. In particular, dissection forces in the ATA were the highest and the separation of the intima-media interface required significantly the lowest force. Moreover, dissection in the longitudinal direction of the vessel generally required more force than in the circumferential one. These results emphasise the need to characterise aortic tissue considering the specific location and dissected layer of the vessel.
000120972 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FSE/T24-20R$$9info:eu-repo/grantAgreement/ES/DGA-IIU/1408-2018$$9info:eu-repo/grantAgreement/ES/MICINN/PID2019-107517RB-I00$$9info:eu-repo/grantAgreement/ES/UZ/ICTS NANBIOSIS-U13 Unit-CIBER-BBN
000120972 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000120972 590__ $$a3.5$$b2022
000120972 592__ $$a0.789$$b2022
000120972 591__ $$aBIOPHYSICS$$b21 / 70 = 0.3$$c2022$$dQ2$$eT1
000120972 593__ $$aMechanical Engineering$$c2022$$dQ1
000120972 591__ $$aENGINEERING, BIOMEDICAL$$b51 / 96 = 0.531$$c2022$$dQ3$$eT2
000120972 593__ $$aModeling and Simulation$$c2022$$dQ1
000120972 593__ $$aBiotechnology$$c2022$$dQ2
000120972 594__ $$a6.7$$b2022
000120972 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000120972 700__ $$0(orcid)0000-0002-8375-0354$$aMartínez, Miguel Ángel$$uUniversidad de Zaragoza
000120972 700__ $$0(orcid)0000-0002-0664-5024$$aPeña, Estefanía$$uUniversidad de Zaragoza
000120972 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000120972 773__ $$g21, 6 (2022), 1887-1901$$pBiomech. model. mechanobiol.$$tBIOMECHANICS AND MODELING IN MECHANOBIOLOGY$$x1617-7959
000120972 8564_ $$s6284109$$uhttps://zaguan.unizar.es/record/120972/files/texto_completo.pdf$$yVersión publicada
000120972 8564_ $$s2390035$$uhttps://zaguan.unizar.es/record/120972/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000120972 909CO $$ooai:zaguan.unizar.es:120972$$particulos$$pdriver
000120972 951__ $$a2024-03-18-15:31:34
000120972 980__ $$aARTICLE