120972 20240319081015.0 doi 10.1007/s10237-022-01627-9 sideral 131483 ART-2022-131483 eng Ríos-Ruiz, Itziar Universidad de Zaragoza (orcid)0000-0003-4128-2836 Is location a significant parameter in the layer dependent dissection properties of the aorta? 2022 Access copy available to the general public Unrestricted Proper characterisation of biological tissue is key to understanding the effect of the biomechanical environment in the physiology and pathology of the cardiovascular system. Aortic dissection in particular is a prevalent and sometimes fatal disease that still lacks a complete comprehension of its progression. Its development and outcome, however, depend on the location in the vessel. Dissection properties of arteries are frequently studied via delamination tests, such as the T-peel test and the mixed-mode peel test. So far, a study that performs both tests throughout different locations of the aorta, as well as dissecting several interfaces, is missing. This makes it difficult to extract conclusions in terms of vessel heterogeneity, as a standardised experimental procedure cannot be assured for different studies in literature. Therefore, both dissection tests have been here performed on healthy porcine aortas, dissecting three interfaces of the vessels, i.e., the intima-media, the media-adventitia and the media within itself, considering different locations of the aorta, the ascending thoracic aorta (ATA), the descending thoracic aorta and the infrarenal abdominal aorta (IAA). Significant differences were found for both, layers and location. In particular, dissection forces in the ATA were the highest and the separation of the intima-media interface required significantly the lowest force. Moreover, dissection in the longitudinal direction of the vessel generally required more force than in the circumferential one. These results emphasise the need to characterise aortic tissue considering the specific location and dissected layer of the vessel. info:eu-repo/grantAgreement/ES/DGA-FSE/T24-20R info:eu-repo/grantAgreement/ES/DGA-IIU/1408-2018 info:eu-repo/grantAgreement/ES/MICINN/PID2019-107517RB-I00 info:eu-repo/grantAgreement/ES/UZ/ICTS NANBIOSIS-U13 Unit-CIBER-BBN info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 3.5 2022 BIOPHYSICS 21 / 70 = 0.3 2022 Q2 T1 ENGINEERING, BIOMEDICAL 51 / 96 = 0.531 2022 Q3 T2 0.789 2022 Mechanical Engineering 2022 Q1 Modeling and Simulation 2022 Q1 Biotechnology 2022 Q2 6.7 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Martínez, Miguel Ángel Universidad de Zaragoza (orcid)0000-0002-8375-0354 Peña, Estefanía Universidad de Zaragoza (orcid)0000-0002-0664-5024 5004 605 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Mec.Med.Cont. y Teor.Est. 21, 6 (2022), 1887-1901 Biomech. model. mechanobiol. BIOMECHANICS AND MODELING IN MECHANOBIOLOGY 1617-7959 6284109 http://zaguan.unizar.es/record/120972/files/texto_completo.pdf Versión publicada 2390035 http://zaguan.unizar.es/record/120972/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:120972 articulos driver 2024-03-18-15:31:34 ARTICLE