000120977 001__ 120977
000120977 005__ 20240319081016.0
000120977 0247_ $$2doi$$a10.1364/BOE.473534
000120977 0248_ $$2sideral$$a131303
000120977 037__ $$aART-2022-131303
000120977 041__ $$aeng
000120977 100__ $$aMiazdzyk, Maria
000120977 245__ $$aAssessing and compensating for the confounding factors in Scheimpflug-based corneal densitometry
000120977 260__ $$c2022
000120977 5060_ $$aAccess copy available to the general public$$fUnrestricted
000120977 5203_ $$aScheimpflug-based corneal densitometry is a clinically verified method for assessing corneal transparency. Nevertheless, the estimates of corneal densitometry appear to be correlated with age and eye biometry parameters, such as the anterior chamber depth or the pupil size, and that ensues a convoluted conditional estimation problem, where it is difficult to interpret the results. This study aims at devising a methodology for compensating for such confounding factors by using, as a research platform, a commercially available Scheimpflug camera that allows exporting images in a dynamic fashion, allowing averaging the results from multiple acquisitions. Two approaches are considered, one based on appropriately normalizing the line densitometry signal and one based on image histogram equalization. Then, three parameters for describing corneal densitometry are derived including the mean value of backscatter and the scale and shape parameters of the Weibull distribution estimated in regions of interest encompassing parts of corneal stroma. The results show that, unlike the non-normalized measures, the proposed approaches lead to parameters that are not correlated with age nor the eye biometry.
000120977 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000120977 590__ $$a3.4$$b2022
000120977 592__ $$a0.955$$b2022
000120977 591__ $$aBIOCHEMICAL RESEARCH METHODS$$b28 / 77 = 0.364$$c2022$$dQ2$$eT2
000120977 593__ $$aBiotechnology$$c2022$$dQ1
000120977 591__ $$aRADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING$$b43 / 135 = 0.319$$c2022$$dQ2$$eT1
000120977 593__ $$aAtomic and Molecular Physics, and Optics$$c2022$$dQ1
000120977 591__ $$aOPTICS$$b36 / 99 = 0.364$$c2022$$dQ2$$eT2
000120977 594__ $$a6.7$$b2022
000120977 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000120977 700__ $$0(orcid)0000-0001-5186-1837$$aConsejo, Alejandra$$uUniversidad de Zaragoza
000120977 700__ $$aIskander, D. Robert
000120977 7102_ $$12002$$2385$$aUniversidad de Zaragoza$$bDpto. Física Aplicada$$cÁrea Física Aplicada
000120977 773__ $$g13, 12 (2022), 6258-6272$$pBIOMEDICAL OPTICS EXPRESS$$tBiomedical Optics Express$$x2156-7085
000120977 8564_ $$s10032614$$uhttps://zaguan.unizar.es/record/120977/files/texto_completo.pdf$$yVersión publicada
000120977 8564_ $$s2504582$$uhttps://zaguan.unizar.es/record/120977/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000120977 909CO $$ooai:zaguan.unizar.es:120977$$particulos$$pdriver
000120977 951__ $$a2024-03-18-15:43:13
000120977 980__ $$aARTICLE