000121002 001__ 121002
000121002 005__ 20240319081022.0
000121002 0247_ $$2doi$$a10.1161/JAHA.121.025897
000121002 0248_ $$2sideral$$a131307
000121002 037__ $$aART-2022-131307
000121002 041__ $$aeng
000121002 100__ $$0(orcid)0000-0003-4130-5866$$aRamírez, Julia$$uUniversidad de Zaragoza
000121002 245__ $$aECG T-Wave Morphologic Variations Predict Ventricular Arrhythmic Risk in Low- and Moderate-Risk Populations
000121002 260__ $$c2022
000121002 5060_ $$aAccess copy available to the general public$$fUnrestricted
000121002 5203_ $$aBackground
Early identification of individuals at risk of sudden cardiac death (SCD) remains a major challenge. The ECG is a simple, common test, with potential for large‐scale application. We developed and tested the predictive value of a novel index quantifying T‐wave morphologic variations with respect to a normal reference (TMV), which only requires one beat and a single‐lead ECG.
Methods and Results
We obtained reference T‐wave morphologies from 23 962 participants in the UK Biobank study. With Cox models, we determined the association between TMV and life‐threatening ventricular arrhythmia in an independent data set from UK Biobank study without a history of cardiovascular events (N=51 794; median follow‐up of 122 months) and SCD in patients with coronary artery disease from ARTEMIS (N=1872; median follow‐up of 60 months). In UK Biobank study, 220 (0.4%) individuals developed life‐threatening ventricular arrhythmias. TMV was significantly associated with life‐threatening ventricular arrhythmias (hazard ratio [HR] of 1.13 per SD increase [95% CI, 1.03–1.24]; P=0.009). In ARTEMIS, 34 (1.8%) individuals reached the primary end point. Patients with TMV ≥5 had an HR for SCD of 2.86 (95% CI, 1.40–5.84; P=0.004) with respect to those with TMV <5, independently from QRS duration, corrected QT interval, and left ventricular ejection fraction. TMV was not significantly associated with death from a cause other than SCD.
Conclusions
TMV identifies individuals at life‐threatening ventricular arrhythmia and SCD risk using a single‐beat single‐lead ECG, enabling inexpensive, quick, and safe risk assessment in large populations.
000121002 536__ $$9info:eu-repo/grantAgreement/EC/H2020/786833/EU/GENetics and the Electrocardiogram for predicting Scd rISk/GENESIS$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 786833-GENESIS
000121002 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000121002 590__ $$a5.4$$b2022
000121002 592__ $$a2.079$$b2022
000121002 591__ $$aCARDIAC & CARDIOVASCULAR SYSTEMS$$b39 / 143 = 0.273$$c2022$$dQ2$$eT1
000121002 593__ $$aCardiology and Cardiovascular Medicine$$c2022$$dQ1
000121002 594__ $$a8.6$$b2022
000121002 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000121002 700__ $$aKiviniemi, Antti
000121002 700__ $$avan Duijvenboden, Stefan
000121002 700__ $$aTinker, Andrew
000121002 700__ $$aLambiase, Pier D.
000121002 700__ $$aJunttila, Juhani
000121002 700__ $$aPerkiömäki, Juha S.
000121002 700__ $$aHuikuri, Heikki V.
000121002 700__ $$aOrini, Michele
000121002 700__ $$aMunroe, Patricia B.
000121002 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000121002 773__ $$g11, 17 (2022), e025897 [41 pp.]$$tJournal of the American Heart Association. Cardiovascular and cerebrovascular disease$$x2047-9980
000121002 8564_ $$s2266258$$uhttps://zaguan.unizar.es/record/121002/files/texto_completo.pdf$$yVersión publicada
000121002 8564_ $$s2697966$$uhttps://zaguan.unizar.es/record/121002/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000121002 909CO $$ooai:zaguan.unizar.es:121002$$particulos$$pdriver
000121002 951__ $$a2024-03-18-16:21:31
000121002 980__ $$aARTICLE