121055 20240319081025.0 doi 10.1016/j.autrev.2022.103167 sideral 130383 ART-2022-130383 eng Carbonell, Cristina Standardized incidence ratios and risk factors for cancer in patients with systemic sclerosis: Data from the Spanish Scleroderma Registry (RESCLE) 2022 Access copy available to the general public Unrestricted Aim Patients with systemic sclerosis (SSc) are at increased risk of cancer, a growing cause of non–SSc-related death among these patients. We analyzed the increased cancer risk among Spanish patients with SSc using standardized incidence ratios (SIRs) and identified independent cancer risk factors in this population. Material and methods Spanish Scleroderma Registry data were analyzed to determine the demographic characteristics of patients with SSc, and logistic regression was used to identify cancer risk factors. SIRs with 95% confidence intervals (CIs) relative to the general Spanish population were calculated. Results Of 1930 patients with SSc, 206 had cancer, most commonly breast, lung, hematological, and colorectal cancers. Patients with SSc had increased risks of overall cancer (SIR 1.48, 95% CI 1.36–1.60; P < 0.001), and of lung (SIR 2.22, 95% CI 1.77–2.73; P < 0.001), breast (SIR 1.31, 95% CI 1.10–1.54; P = 0.003), and hematological (SIR 2.03, 95% CI 1.52–2.62; P < 0.001) cancers. Cancer was associated with older age at SSc onset (odds ratio [OR] 1.22, 95% CI 1.01–1.03; P < 0.001), the presence of primary biliary cholangitis (OR 2.35, 95% CI 1.18–4.68; P = 0.015) and forced vital capacity <70% (OR 1.8, 95% CI 1.24–2.70; P = 0.002). The presence of anticentromere antibodies lowered the risk of cancer (OR 0.66, 95% CI 0.45–0.97; P = 0.036). Conclusions Spanish patients with SSc had an increased cancer risk compared with the general population. Some characteristics, including specific autoantibodies, may be related to this increased risk. info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 13.6 2022 IMMUNOLOGY 12 / 161 = 0.075 2022 Q1 T1 2.552 2022 Immunology and Allergy 2022 Q1 Immunology 2022 Q1 23.3 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Marcos, Miguel Guillén-del-Castillo, Alfredo Rubio-Rivas, Manuel Argibay, Ana Marín-Ballvé, Adela Rodríguez-Pintó, Ignasi Baldà-Masmiquel, Maria Callejas-Moraga, Eduardo Colunga, Dolores Sáez-Comet, Luis Universidad de Zaragoza (orcid)0000-0002-9868-6498 González-Echávarri, Cristina Ortego-Centeno, Norberto Marí-Alfonso, Begoña Vargas-Hitos, José-Antonio Todolí-Parra, José-Antonio Trapiella, Luis Herranz-Marín, María-Teresa Freire, Mayka Castro-Salomó, Antoni Perales-Fraile, Isabel Madroñero-Vuelta, Ana-Belén Sánchez-García, María-Esther Ruiz-Muñoz, Manuel González-García, Andrés Sánchez-Redondo, Jorge de-la-Red-Bellvis, Gloria Fernández-Luque, Alejandra Muela-Molinero, Alberto Lledó, Gema-María Tolosa-Vilella, Carles Fonollosa-Pla, Vicent Chamorro, Antonio-Javier Simeón-Aznar, Carmen-Pilar 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 21, 10 (2022), 103167 [10 pp.] Autoimmun. Rev. AUTOIMMUNITY REVIEWS 1568-9972 647327 http://zaguan.unizar.es/record/121055/files/texto_completo.pdf Versión publicada 2443402 http://zaguan.unizar.es/record/121055/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:121055 articulos driver 2024-03-18-16:36:08 ARTICLE