121068 20240319080948.0 doi 10.1002/smi.3088 sideral 125890 ART-2022-125890 eng Montoliu T. Mediation of perceived stress and cortisol in the association between neuroticism and global cognition in older adults: A longitudinal study 2022 Access copy available to the general public Unrestricted Neuroticism has been associated with a greater dementia risk, but its association with cognitive decline in healthy older adults remains unclear. Stress has been proposed as one of the mechanisms that could explain this relationship. Our aim was to analyse, in healthy older people, the mediating role of perceived stress and the Hypothalamic–Pituitary–Adrenal (HPA) axis in the association between neuroticism and global cognition. At Waves 1 and 2 (4-year follow-up), 87 older people (49.4% women; M age = 65.08, SD = 4.54 at Wave 1) completed a neuropsychological battery and the Perceived Stress Scale (PSS), and provided saliva samples on two (Wave 1) and three (Wave 2) consecutive days to measure the wake-to-bed slope. In Wave 2, neuroticism was assessed with the NEO-Five-Factor Inventory. PSS, but not the wake-to-bed slope, mediated the negative associations between neuroticism and global cognition (Waves 1, 2 and change). Regarding gender differences, PSS (Waves 1, 2 and change) and the wake-to-bed slope (Wave 2 and change) mediated these associations in men. Our results suggest that perceived stress and HPA-axis dysregulation could act as mechanisms underlying the association between neuroticism and cognitive functioning and decline, at least in older men. © 2021. The Authors. Stress and Health published by John Wiley & Sons Ltd. info:eu-repo/grantAgreement/ES/DGA-FEDER/Construyendo Europa desde Aragón info:eu-repo/grantAgreement/ES/DGA-FEDER/S31-20D info:eu-repo/grantAgreement/ES/MEC/PSI2013-46889 info:eu-repo/grantAgreement/ES/MEC/PSI2016-78763 info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 4.1 2022 PSYCHOLOGY 17 / 81 = 0.21 2022 Q1 T1 PSYCHOLOGY, APPLIED 26 / 83 = 0.313 2022 Q2 T1 PSYCHIATRY 49 / 143 = 0.343 2022 Q2 T2 PSYCHIATRY 66 / 154 = 0.429 2022 Q2 T2 1.196 2022 Applied Psychology 2022 Q1 Psychiatry and Mental Health 2022 Q1 Medicine (miscellaneous) 2022 Q1 Clinical Psychology 2022 Q1 5.4 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Pulopulos M.M. Universidad de Zaragoza (orcid)0000-0002-7048-3795 Puig-Pérez S. Hidalgo V. Universidad de Zaragoza (orcid)0000-0003-3920-1099 Salvador A. 4009 725 Universidad de Zaragoza Dpto. Psicología y Sociología Área Psicobiología 38, 2 (2022), 290-303 Stress health Stress and Health 1532-3005 709794 http://zaguan.unizar.es/record/121068/files/texto_completo.pdf Versión publicada 2189724 http://zaguan.unizar.es/record/121068/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:121068 articulos driver 2024-03-18-12:45:05 ARTICLE