121070 20240319080948.0 doi 10.1080/02713683.2021.1951301 sideral 126075 ART-2022-126075 eng Cordon, B. Universidad de Zaragoza Analysis of Retinal Layers in Fibromyalgia Patients with Premium Protocol in Optical Tomography Coherence and Quality of Life 2022 Access copy available to the general public Unrestricted Purpose To evaluate the inner retinal layers in fibromyalgia (FM) patients compared to control subjects using posterior pole protocol (PPole) analysis in optical coherence tomography (OCT) and to correlate structural retinal changes with subjective quality of life. Methods Seventy-four eyes of healthy subjects and 55 eyes of those with FM were analyzed. All subjects underwent retinal evaluation using the PPole protocol for Spectralis OCT (Heidelberg Engineering) to obtain measurements of the retinal nerve fiber layer (RNFL) and the ganglion cell layer (GCL) in the macular area. The EuroQol (EQ-5D) questionnaire and Fibromyalgia Impact Questionnaire (FIQ) were performed to analyze health-related quality of life. Additionally, the FM group was divided into three groups depending on the disease phenotype (atypical, depressive, and biological). Results Patients with FM presented with a reduction of the RNFL thickness compared to controls in 17/64 cells of the PPole area, and a reduction of the GCL thickness in 47/64 cells. Depressive FM phenotype showed the greatest number of cells with significant reduction compared with the control group in both RNFL and GCL layers. A correlation between temporal-inferior cells of the GCL and the EuroQol 5D questionnaire results was observed. Conclusions Patients with FM present with a reduction of the inner retinal layers in the macular area. This degeneration correlates with disease severity/reduced quality of life in these patients. The PPole protocol for OCT is a non-invasive and fast tool that might help clinicians diagnose and monitor neurodegeneration in FM patients. info:eu-repo/grantAgreement/ES/ISCIII/PI17-01726 info:eu-repo/grantAgreement/ES/ISCIII/PI17-01946 info:eu-repo/grantAgreement/ES/ISCIII/PI20-00437 info:eu-repo/grantAgreement/ES/MINECO/MAT2017-83858-C2-2 info:eu-repo/semantics/openAccess by-nc http://creativecommons.org/licenses/by-nc/3.0/es/ 2.0 2022 OPHTHALMOLOGY 37 / 62 = 0.597 2022 Q3 T2 0.639 2022 Ophthalmology 2022 Q2 Sensory Systems 2022 Q3 Cellular and Molecular Neuroscience 2022 Q4 4.3 2022 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Orduna, E. Universidad de Zaragoza (orcid)0000-0003-2710-1875 Viladés, E. Universidad de Zaragoza (orcid)0000-0001-9411-5834 Garcia-Martin, E Universidad de Zaragoza (orcid)0000-0001-6258-2489 Garcia-Campayo, J. Universidad de Zaragoza (orcid)0000-0002-3797-4218 Puebla-Guedea, M. Universidad de Zaragoza (orcid)0000-0002-8862-7240 Polo, V. Universidad de Zaragoza (orcid)0000-0002-1402-3129 Larrosa, J.M. Universidad de Zaragoza (orcid)0000-0002-6745-7668 Pablo, L.E. Universidad de Zaragoza (orcid)0000-0003-2389-8282 Vicente, M.J. Satue, M. Universidad de Zaragoza (orcid)0000-0002-1609-5994 1013 646 Universidad de Zaragoza Dpto. Cirugía Área Oftalmología 1007 745 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Psiquiatría 2002 647 Universidad de Zaragoza Dpto. Física Aplicada Área Óptica 4009 735 Universidad de Zaragoza Dpto. Psicología y Sociología Área Psicolog.Evolut.Educac 47, 1 (2022), 143-153 Curr. eye res. CURRENT EYE RESEARCH 0271-3683 1535269 http://zaguan.unizar.es/record/121070/files/texto_completo.pdf Postprint 1161133 http://zaguan.unizar.es/record/121070/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:121070 articulos driver 2024-03-18-12:46:03 ARTICLE