000121095 001__ 121095
000121095 005__ 20240319080957.0
000121095 0247_ $$2doi$$a10.1038/s41598-022-24954-4
000121095 0248_ $$2sideral$$a131686
000121095 037__ $$aART-2022-131686
000121095 041__ $$aeng
000121095 100__ $$aRodrigo, María Jesús$$uUniversidad de Zaragoza
000121095 245__ $$aTunable degrees of neurodegeneration in rats based on microsphere-induced models of chronic glaucoma
000121095 260__ $$c2022
000121095 5060_ $$aAccess copy available to the general public$$fUnrestricted
000121095 5203_ $$aThis study compares four different animal models of chronic glaucoma against normal aging over 6 months. Chronic glaucoma was induced in 138 Long–Evans rats and compared against 43 aged-matched healthy rats. Twenty-five rats received episcleral vein sclerosis injections (EPIm cohort) while the rest were injected in the eye anterior chamber with a suspension of biodegradable microspheres: 25 rats received non-loaded microspheres (N-L Ms cohort), 45 rats received microspheres loaded with dexamethasone (MsDexa cohort), and 43 rats received microspheres co-loaded with dexamethasone and fibronectin (MsDexaFibro cohort). Intraocular pressure, neuroretinal function, structure and vitreous interface were evaluated. Each model caused different trends in intraocular pressure, produced specific retinal damage and vitreous signals. The steepest and strongest increase in intraocular pressure was seen in the EPIm cohort and microspheres models were more progressive. The EPIm cohort presented the highest vitreous intensity and percentage loss in the ganglion cell layer, the MsDexa cohort presented the greatest loss in the retinal nerve fiber layer, and the MsDexaFibro cohort presented the greatest loss in total retinal thickness. Function decreased differently among cohorts. Using biodegradable microspheres models it is possible to generate tuned neurodegeneration. These results support the multifactorial nature of glaucoma based on several noxa.
000121095 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/M17-00213$$9info:eu-repo/grantAgreement/ES/ISCIII/PI17-01726$$9info:eu-repo/grantAgreement/ES/ISCIII/PI17-01946$$9info:eu-repo/grantAgreement/ES/ISCIII-RICORDS/RD21-0002-0050$$9info:eu-repo/grantAgreement/ES/MICINN/MAT2017-83858-C2-1$$9info:eu-repo/grantAgreement/ES/MICINN/MAT2017-83858-C2-2$$9info:eu-repo/grantAgreement/ES/MICINN/PID2020-113281RB-C21$$9info:eu-repo/grantAgreement/ES/MICINN/PID2020-113281RB-C22$$9info:eu-repo/grantAgreement/ES/MICINN/PRE2018-083951
000121095 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000121095 590__ $$a4.6$$b2022
000121095 592__ $$a0.973$$b2022
000121095 591__ $$aMULTIDISCIPLINARY SCIENCES$$b22 / 73 = 0.301$$c2022$$dQ2$$eT1
000121095 593__ $$aMultidisciplinary$$c2022$$dQ1
000121095 594__ $$a7.5$$b2022
000121095 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000121095 700__ $$aBravo-Osuna, Irene
000121095 700__ $$aSubias, Manuel$$uUniversidad de Zaragoza
000121095 700__ $$0(orcid)0000-0001-7248-4399$$aMontolío, Alberto$$uUniversidad de Zaragoza
000121095 700__ $$0(orcid)0000-0002-2967-6747$$aCegoñino, José$$uUniversidad de Zaragoza
000121095 700__ $$aMartinez-Rincón, Teresa$$uUniversidad de Zaragoza
000121095 700__ $$0(orcid)0000-0001-6072-1545$$aMendez-Martinez, Silvia$$uUniversidad de Zaragoza
000121095 700__ $$aAragón-Navas, Alba
000121095 700__ $$aGarcia-Herranz, David
000121095 700__ $$0(orcid)0000-0003-2389-8282$$aPablo, Luis Emilio$$uUniversidad de Zaragoza
000121095 700__ $$aHerrero-Vanrell, Rocío
000121095 700__ $$0(orcid)0000-0003-0669-777X$$aPérez del Palomar, Amaya$$uUniversidad de Zaragoza
000121095 700__ $$0(orcid)0000-0001-6258-2489$$aGarcia-Martin, Elena$$uUniversidad de Zaragoza
000121095 7102_ $$11013$$2645$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Obstetricia y Ginecología
000121095 7102_ $$11013$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Oftalmología
000121095 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000121095 773__ $$g12 (2022), 20622 [15 pp.]$$pSci. rep. (Nat. Publ. Group)$$tScientific reports (Nature Publishing Group)$$x2045-2322
000121095 8564_ $$s4407370$$uhttps://zaguan.unizar.es/record/121095/files/texto_completo.pdf$$yVersión publicada
000121095 8564_ $$s2536847$$uhttps://zaguan.unizar.es/record/121095/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000121095 909CO $$ooai:zaguan.unizar.es:121095$$particulos$$pdriver
000121095 951__ $$a2024-03-18-13:42:06
000121095 980__ $$aARTICLE