000121119 001__ 121119
000121119 005__ 20240319081005.0
000121119 0247_ $$2doi$$a10.1063/5.0084228
000121119 0248_ $$2sideral$$a131417
000121119 037__ $$aART-2022-131417
000121119 041__ $$aeng
000121119 100__ $$0(orcid)0000-0003-1558-9279$$aGoya, G. F.$$uUniversidad de Zaragoza
000121119 245__ $$aPublisher’s Note: “Next generation of nanozymes: A perspective of the challenges to match biological performance” [J. Appl. Phys. 130, 190903 (2021)]
000121119 260__ $$c2022
000121119 5060_ $$aAccess copy available to the general public$$fUnrestricted
000121119 5203_ $$aNanomaterials with enzyme-like activity have been the spotlight of scientific and technological efforts to substitute natural enzymes, not only in biological research but also for industrial manufacturing, medicine, and environment healing. Notable advancements in this field along the last years relied on to the rational design of single-atom active sites, knowledge of the underlying atomic structure, and realistic ab initio theoretical models of the electronic configuration at the active site. Thus, it is plausible that a next generation of nanozymes still to come will show even improved catalytic efficiency and substrate specificity. However, the dynamic nature of the protein cage surrounding most active sites in biological enzymes adds a flexible functionality that possess a challenge for nanozyme's mimicking of their natural counterparts. We offer a perspective about where the main strategies to improve nanozymes are headed and identify some of the big challenges faced along the road to better performance. We also outline some of the most exciting bio-inspired ideas that could potentially change this field.
000121119 536__ $$9info:eu-repo/grantAgreement/ES/DGA/E13-20R$$9info:eu-repo/grantAgreement/ES/DGA/E28-20R$$9info:eu-repo/grantAgreement/EC/H2020/101007629 /EU/Nanomaterials for Enzymatic Control of Oxidative Stress Toxicity and Free Radical Generation/NESTOR$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 101007629 -NESTOR$$9info:eu-repo/grantAgreement/EC/H2020/823717/EU/Enabling Science and Technology through European Electron Microscopy/ESTEEM3$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 823717-ESTEEM3$$9info:eu-repo/grantAgreement/ES/MCIU/RTC-2017-6620-1$$9info:eu-repo/grantAgreement/ES/MICIU/PID2019-106947RB-C21
000121119 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000121119 590__ $$a3.2$$b2022
000121119 592__ $$a0.706$$b2022
000121119 591__ $$aPHYSICS, APPLIED$$b62 / 160 = 0.387$$c2022$$dQ2$$eT2
000121119 593__ $$aPhysics and Astronomy (miscellaneous)$$c2022$$dQ2
000121119 594__ $$a5.1$$b2022
000121119 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000121119 700__ $$0(orcid)0000-0002-5229-2717$$aMayoral, A.$$uUniversidad de Zaragoza
000121119 700__ $$aWinkler, E.
000121119 700__ $$aZysler, R. D.
000121119 700__ $$aBagnato, C.
000121119 700__ $$aRaineri, M.
000121119 700__ $$aFuentes García, J. A.$$uUniversidad de Zaragoza
000121119 700__ $$aLima, E.
000121119 7102_ $$12003$$2395$$aUniversidad de Zaragoza$$bDpto. Física Materia Condensa.$$cÁrea Física Materia Condensada
000121119 773__ $$g131, 3 (2022), 039903 [2 pp]$$pJ. appl. physi.$$tJournal of Applied Physics$$x0021-8979
000121119 8564_ $$s18908813$$uhttps://zaguan.unizar.es/record/121119/files/texto_completo.pdf$$yPostprint
000121119 8564_ $$s2503597$$uhttps://zaguan.unizar.es/record/121119/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000121119 909CO $$ooai:zaguan.unizar.es:121119$$particulos$$pdriver
000121119 951__ $$a2024-03-18-14:34:41
000121119 980__ $$aARTICLE