121120 20240319081005.0 doi 10.3390/healthcare10050798 sideral 129158 ART-2022-129158 eng Castellar Otín, Carlos Universidad de Zaragoza (orcid)0000-0003-1121-6408 Bone turnover alterations after completing a multistage ultra-trail: a case study 2022 Access copy available to the general public Unrestricted A series of case studies aimed to assess bone and stress fractures in a 768-km ultra-trail race for 11 days. Four nonprofessional male athletes completed the event without diagnosing any stress fracture. Bone turnover markers (osteocalcin (OC), serum C-terminal cross-linking telopeptide of type I collagen (CTX), bone-specific alkaline phosphatase (BALP), and serum turnover calcium (Ca2+)) were assessed before (pre) and after the race (post) and on days two and nine during the recovery period (rec2 and rec9), respectively. Results showed: post-pre-OC = -45.78%, BALP = -61.74%, CTX = +37.28% and Ca2+ = -3.60%. At rec2 and rec9, the four parameters did not return to their pre-run levels: OC, -48.31%; BALP, -61.66%; CTX, +11.93% and Ca2+, -3.38%; and OC = -25.12%, BALP = -54.65%, CTX = +93.41% and Ca2+ = +3.15%), respectively. Our results indicated that the ultra-trail race induced several changes in bone turnover markers, uncoupling of bone metabolism, increased bone resorption: OC and BALP and suppressed bone formation: CTX and Ca2+. Bone turnover markers can help determine the response of bone to extreme effort and might also help predict the risk of stress fractures. © 2022 by the authors. Licensee MDPI, Basel, Switzerland. info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 2.8 2022 HEALTH POLICY & SERVICES 43 / 87 = 0.494 2022 Q2 T2 HEALTH CARE SCIENCES & SERVICES 57 / 106 = 0.538 2022 Q3 T2 0.55 2022 Health Policy 2022 Q2 Leadership and Management 2022 Q2 Health Informatics 2022 Q3 Health Information Management 2022 Q3 2.7 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Lecina, Miguel Pradas, Francisco Universidad de Zaragoza (orcid)0000-0002-6829-0775 3001 187 Universidad de Zaragoza Dpto. Expres.Music.Plást.Corp. Área Didáctica Expres.Corporal 10, 5 (2022), 798 [10 pp.] Healthcare (Basel) Healthcare (Switzerland) 2227-9032 662616 http://zaguan.unizar.es/record/121120/files/texto_completo.pdf Versión publicada 2683148 http://zaguan.unizar.es/record/121120/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:121120 articulos driver 2024-03-18-14:36:07 ARTICLE