000121135 001__ 121135
000121135 005__ 20240319081007.0
000121135 0247_ $$2doi$$a10.1039/d2na00015f
000121135 0248_ $$2sideral$$a131822
000121135 037__ $$aART-2022-131822
000121135 041__ $$aeng
000121135 100__ $$aMekseriwattana, Wid
000121135 245__ $$aRiboflavin–citrate conjugate multicore SPIONs with enhanced magnetic responses and cellular uptake in breast cancer cells
000121135 260__ $$c2022
000121135 5060_ $$aAccess copy available to the general public$$fUnrestricted
000121135 5203_ $$aBreast cancer accounts for up to 10% of the newly diagnosed cancer cases worldwide, making it the most common cancer found in women. The use of superparamagnetic iron oxide nanoparticles (SPIONs) has been beneficial in the advancement of contrast agents and magnetic hyperthermia (MH) for the diagnosis and treatment of cancers. To achieve delivery of SPIONs to cancer cells, surface functionalization with specific ligands are required. Riboflavin carrier protein (RCP) has been identified as an alternative target for breast cancer cells. Here, we report a novel riboflavin (Rf)-based ligand that provides SPIONs with enhanced colloidal stability and high uptake potential in breast cancer cells. This is achieved by synthesizing an Rf-citrate ligand. The ligand was tested in a multicore SPION system, and affinity to RCP was assessed by isothermal titration calorimetry which showed a specific, entropy-driven binding. MRI and MH responses of the coated Rf-SPIONs were tested to evaluate the suitability of this system as a theranostic platform. Finally, interaction of the Rf-SPIONs with breast cancer cells was evaluated by in vitro cellular uptake in MCF-7 breast cancer cells. The overall characterization of the Rf-SPIONs highlighted the excellent performance of this platform for theranostic applications in breast cancer.
000121135 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FSE/E15-20R$$9info:eu-repo/grantAgreement/ES/MICIU/CEX2019-000917-S$$9info:eu-repo/grantAgreement/ES/MICIU/RyC2019-028414-I
000121135 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000121135 590__ $$a4.7$$b2022
000121135 592__ $$a1.063$$b2022
000121135 591__ $$aMATERIALS SCIENCE, MULTIDISCIPLINARY$$b123 / 343 = 0.359$$c2022$$dQ2$$eT2
000121135 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b61 / 178 = 0.343$$c2022$$dQ2$$eT2
000121135 591__ $$aNANOSCIENCE & NANOTECHNOLOGY$$b55 / 107 = 0.514$$c2022$$dQ3$$eT2
000121135 593__ $$aAtomic and Molecular Physics, and Optics$$c2022$$dQ1
000121135 593__ $$aBioengineering$$c2022$$dQ1
000121135 593__ $$aMaterials Science (miscellaneous)$$c2022$$dQ1
000121135 593__ $$aEngineering (miscellaneous)$$c2022$$dQ1
000121135 593__ $$aChemistry (miscellaneous)$$c2022$$dQ1
000121135 594__ $$a8.6$$b2022
000121135 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000121135 700__ $$aGuardia, Pablo
000121135 700__ $$aTorres Herrero, Beatriz
000121135 700__ $$0(orcid)0000-0003-1081-8482$$ade la Fuente, Jesus M.
000121135 700__ $$aKuhakarn, Chutima
000121135 700__ $$aRoig, Anna
000121135 700__ $$aKatewongsa, Kanlaya Prapainop
000121135 773__ $$g4, 8 (2022), 1988-1998$$tNanoscale Advances$$x2516-0230
000121135 8564_ $$s1393627$$uhttps://zaguan.unizar.es/record/121135/files/texto_completo.pdf$$yVersión publicada
000121135 8564_ $$s2844563$$uhttps://zaguan.unizar.es/record/121135/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000121135 909CO $$ooai:zaguan.unizar.es:121135$$particulos$$pdriver
000121135 951__ $$a2024-03-18-14:46:54
000121135 980__ $$aARTICLE